( super(125)I)-1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane: An iodinated radioligand that specifically labels the agonist high-affinity state of 5-HT sub(2) serotonin receptors

The authors have demonstrated that certain phenalkylamine derivatives possess a high affinity and selectivity for a particular population of 5-HT sites (i.e., 5-HT sub(2) sites); such agents include 1-(2,5-dimethoxy-4-X-phenyl)-2-aminopropane where X = Br (DOB; 1, R = Br) and X = iodo (DOI; 1, R = I...

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Bibliographic Details
Published in:Journal of medicinal chemistry 1988-01, Vol.31 (1), p.5-7
Main Authors: Summers, J B, Gunn, B P, Martin, J G, Mazdiyasni, H, Stewart, A O, Young, PR, Goetze, A M, Bouska, J B, Dyer, R D
Format: Article
Language:English
Online Access:Get full text
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Summary:The authors have demonstrated that certain phenalkylamine derivatives possess a high affinity and selectivity for a particular population of 5-HT sites (i.e., 5-HT sub(2) sites); such agents include 1-(2,5-dimethoxy-4-X-phenyl)-2-aminopropane where X = Br (DOB; 1, R = Br) and X = iodo (DOI; 1, R = I). They report the synthesis and preliminary evaluation of a radioiodinated ligand, ( super(125)I)DOI (1, R = super(125)I), that should prove useful for future 5-HT sub(2) studies.
ISSN:0022-2623