Role of perfusion computed tomography in assessing submandibular gland radiochemotherapy-induced injury

Objective We aimed to detect changes in the volume and perfusion parameters of the submandibular glands during and after radiochemotherapy. Study Design Twelve patients underwent computed tomography (CT) and perfusion CT before radiochemotherapy, after 40 Gy, after 70 Gy, and 3 months after radioche...

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Published in:Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2014-08, Vol.118 (2), p.241-247
Main Authors: Popovic, Katarina Surlan, MD, PhD, Harej, Maja, MD, Furlan, Tjaša, MD, Popovič, Peter, MD, PhD, Strojan, Primož, MD, PhD
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma, Squamous Cell - diagnostic imaging
Carcinoma, Squamous Cell - therapy
Chemoradiotherapy - adverse effects
Dentistry
Female
Humans
Male
Middle Aged
Mouth Neoplasms - diagnostic imaging
Mouth Neoplasms - therapy
Radiographic Image Interpretation, Computer-Assisted
Radiotherapy Dosage
Submandibular Gland - diagnostic imaging
Submandibular Gland - radiation effects
Surgery
Tomography, X-Ray Computed - methods
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Summary:Objective We aimed to detect changes in the volume and perfusion parameters of the submandibular glands during and after radiochemotherapy. Study Design Twelve patients underwent computed tomography (CT) and perfusion CT before radiochemotherapy, after 40 Gy, after 70 Gy, and 3 months after radiochemotherapy. Submandibular gland volume, blood volume, permeability surface area product, and blood flow were quantified. Results Submandibular gland volumes during and after therapy were significantly lower compared with the baseline value ( P  
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2014.04.011