Predictive accuracy of first post-treatment PET/CT in HPV-related oropharyngeal squamous cell carcinoma

Objectives/Hypothesis To determine whether the result of first posttreatment positron emission tomography and computed tomography (PET/CT) is predictive of outcome in patients with oropharyngeal squamous cell carcinoma (OPSCC), and whether PET/CT accuracy is affected by human papillomavirus (HPV) st...

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Bibliographic Details
Published in:The Laryngoscope 2014-08, Vol.124 (8), p.1843-1847
Main Authors: Koshkareva, Yekaterina, Branstetter IV, Barton F., Gaughan, John P., Ferris, Robert L.
Format: Article
Language:English
Subjects:
Accuracy
Adult
Aged
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - therapy
Carcinoma, Squamous Cell - virology
Cervical cancer
Disease-Free Survival
Female
head and neck squamous cell carcinoma (HNSCC)
Human papillomavirus
Humans
Male
Medical prognosis
Middle Aged
Multimodal Imaging
Multivariate analysis
Oropharyngeal Neoplasms - diagnosis
Oropharyngeal Neoplasms - therapy
Oropharyngeal Neoplasms - virology
oropharynx
Papillomavirus Infections - complications
PET/CT
Positron-Emission Tomography
Predictive Value of Tests
Retrospective Studies
surveillance
Tomography
Tomography, X-Ray Computed
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Summary:Objectives/Hypothesis To determine whether the result of first posttreatment positron emission tomography and computed tomography (PET/CT) is predictive of outcome in patients with oropharyngeal squamous cell carcinoma (OPSCC), and whether PET/CT accuracy is affected by human papillomavirus (HPV) status. Study Design Retrospective review. Methods Demographic, clinical, and radiographic data were available for 61 patients with OPSCC, treated in 2004 to 2012 at a single tertiary academic referral center, with at least one baseline and one posttreatment PET/CT. Clinical follow‐up was obtained every 3 months thereafter. The median follow‐up time was 36 months (range 3–100 months). Results Of 61 patients, 48 (79%) had negative first posttreatment PET/CT results; and overall, 18 of the 61 patients (30%) recurred. All accuracy measures for PET/CT were higher in HPV‐positive patients, including a 93% negative predictive value (NPV). Patients with positive PET/CT results had poorer survival on Kaplan‐Meier analyses. On multivariate analysis of factors predictive of recurrence, two parameters were significant: HPV status (P = 0.0046) and PET/CT result (P
ISSN:0023-852X
1531-4995
DOI:10.1002/lary.24617