Chronic Inhalation Study of Mice Subjected to Diethlyhdroxylamine, Nitroethane,and Diethylamine Hydrogen Sulfite

Institute of Cancer Research Swiss strain mice were subjected to the inhalation of 10.3 plus or minus 3.7 ppm diethylhydroxylamine, 10.1 plus or minus 4.1 ppm nitroethane, and the vapor of diethylamine hydrogen sulfite for over 2 years. Histopathologic evaluation of all organs indicated only a few s...

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Bibliographic Details
Published in:Environmental research 1982-01, Vol.27 (2), p.277-289
Main Authors: Heicklen, J, Lundgard, R, Partymiller, K, Ferguson, F, Putman, C, Sapanski, W, Tankard, J, Billups, L
Format: Article
Language:English
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Summary:Institute of Cancer Research Swiss strain mice were subjected to the inhalation of 10.3 plus or minus 3.7 ppm diethylhydroxylamine, 10.1 plus or minus 4.1 ppm nitroethane, and the vapor of diethylamine hydrogen sulfite for over 2 years. Histopathologic evaluation of all organs indicated only a few significant findings. The incidence of all tumors, as well as subcutaneous tumors (principally fibosarcomas), increased in exposed males with marginal statistical significance. The incidence of all tumors in exposed females decreased with marked statistical significance.
ISSN:0013-9351