TRENDS IN THE INCIDENCE OF CANCER OF THE CORPUS UTERI IN CONNECTICUT, 1964–1979, IN RELATION TO CONSUMPTION OF EXOGENOUS ESTROGENS

The incidence of cancer of the uterine corpus diagnosed in the localized stage and reported to the Connecticut Tumor Registry changed little between 1964 and 1969. During the next six years, however, it increased substantially, reaching a peak in 1975, followed by an irregular decline through 1979....

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Bibliographic Details
Published in:American journal of epidemiology 1982-07, Vol.116 (1), p.57-67
Main Authors: MARRETT, LORAINE D., MEIGS, J. WISTER, FLANNERY, JOHN T.
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma in Situ - chemically induced
Carcinoma in Situ - epidemiology
Connecticut
Epidemiologic Methods
estrogens
Estrogens - adverse effects
Female
Humans
Middle Aged
Registries
Risk
Time Factors
uterine neoplasms
Uterine Neoplasms - chemically induced
Uterine Neoplasms - epidemiology
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Summary:The incidence of cancer of the uterine corpus diagnosed in the localized stage and reported to the Connecticut Tumor Registry changed little between 1964 and 1969. During the next six years, however, it increased substantially, reaching a peak in 1975, followed by an irregular decline through 1979. Women aged 45-64 years showed both the largest increase and the sharpest decline. The incidence of tumors diagnosed with regional or distant spread has been rising slightly but consistently through the period 1970–1979; this upward trend is statistically significant (p < 0.01). Rates corrected for hysterectomized women not truly at risk are 40–50% higher than uncorrected rates but trends are the same. Explanations which are considered are changes in diagnostic practices and changes in risk factor prevalence. The use of noncontraceptlve oral estrogens, a well documented risk factor for endometrlal cancer, increased between 1964 and 1975 and then declined sharply through 1979 in the United States. The Importance of these compounds in explaining the observed incidence trends is considered in terms of the major time- and stage-specific features of the exogenous estrogen-endometrial cancer association reported in the case-control studies.
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a113402