Spinal bone marrow necrosis with vertebral compression fracture: differentiation of BMN from AVN

Bone marrow necrosis (BMN) is a rare malignancy-associated hematologic disorder characterized by necrosis of myeloid and stromal marrow elements with preservation of cortical bone. Overlap between the imaging appearances of BMN and avascular necrosis (AVN) raises the potential for diagnostic confusi...

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Bibliographic Details
Published in:Skeletal radiology 2014-09, Vol.43 (9), p.1337-1340
Main Authors: Nix, J. S., Fitzgerald, R. T., Samant, R. S., Harrison, M., Angtuaco, E. J.
Format: Article
Language:English
Subjects:
Bone Marrow Diseases - complications
Bone Marrow Diseases - diagnosis
Case Report
Diagnosis, Differential
Fractures
Fractures, Compression - complications
Fractures, Compression - diagnosis
Humans
Imaging
Lumbar Vertebrae - injuries
Lumbar Vertebrae - pathology
Magnetic Resonance Imaging
Male
Medical colleges
Medicine
Medicine & Public Health
Middle Aged
Necrosis
Necrosis - complications
Necrosis - pathology
Nuclear Medicine
Orthopedics
Osteonecrosis - complications
Osteonecrosis - diagnosis
Pathology
Radiology
Spinal Fractures - complications
Spinal Fractures - diagnosis
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Summary:Bone marrow necrosis (BMN) is a rare malignancy-associated hematologic disorder characterized by necrosis of myeloid and stromal marrow elements with preservation of cortical bone. Overlap between the imaging appearances of BMN and avascular necrosis (AVN) raises the potential for diagnostic confusion. We report a case of BMN presenting with a traumatic multi-level vertebral body collapse, and finding that may potentially confound distinction between the two entities. We discuss important pathophysiologic, clinical, and radiologic differences between BMN and AVN with emphasis on features important in the differential diagnosis.
ISSN:0364-2348
1432-2161
DOI:10.1007/s00256-014-1906-6