Rapid and Ultrasensitive Electrochemical Detection of Multidrug-Resistant Bacteria Based on Nanostructured Gold Coated ITO Electrode

Rapid and ultrasensitive detection of pathogenic bacteria and their relevant multidrug resistance is particularly important in clinical diagnosis, disease control, and environmental monitoring. In this contribution, we have explored the possibility to rapidly detect some important disease related ba...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2014-07, Vol.6 (14), p.11025-11031
Main Authors: Lv, Xiayi, Ge, Wei, Li, Qiwei, Wu, Yueli, Jiang, Hui, Wang, Xuemei
Format: Article
Language:English
Subjects:
Biosensing Techniques - methods
Drug Resistance, Multiple, Bacterial
Electrodes
Escherichia coli
Gold - chemistry
Indium - chemistry
Nanostructures - chemistry
Sensitivity and Specificity
Staphylococcus aureus
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Summary:Rapid and ultrasensitive detection of pathogenic bacteria and their relevant multidrug resistance is particularly important in clinical diagnosis, disease control, and environmental monitoring. In this contribution, we have explored the possibility to rapidly detect some important disease related bacteria based on a nanostructured Au modified indium tin oxide electrode through the antibiotic agents such as doxorubicin. The rapid and real-time electrochemical detection of multidrug resistant bacteria like Escherichia coli and Staphylococcus aureus could be readily realized through the nanostructured Au based biosensor with high sensitivity. The observations of surface-enhanced Raman spectroscopy and laser confocal fluorescence microscopy also demonstrate the effectiveness of the relevant new strategy for the rapid and ultrasensitive electrochemical detection of some disease related bacteria.
ISSN:1944-8244
1944-8252
DOI:10.1021/am5016099