Cellular composition and ultrastructure of hepatic neoplasms induced by diethylnitrosamine in Oryzias latipes

In vivo exposure of young Oryzias latipes to the carcinogen, diethylnitrosamine (DENA), results in tumor formation after a brief latent period. 1,2 During serial analysis of cytologic changes accompanying, neoplastic progression, 3 we reported light microscopic alterations and appearance of enzyme-a...

Full description

Saved in:
Bibliographic Details
Published in:Marine environmental research 1988-01, Vol.24 (1), p.307-310
Main Authors: Hinton, David E, Lauren, Darrel J, Teh, Swee J, Giam, C.S
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Chemical agents
Freshwater
Medical sciences
Oryzias latipes
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In vivo exposure of young Oryzias latipes to the carcinogen, diethylnitrosamine (DENA), results in tumor formation after a brief latent period. 1,2 During serial analysis of cytologic changes accompanying, neoplastic progression, 3 we reported light microscopic alterations and appearance of enzyme-altered foci. In addition, we have shown hepatocellular neoplasms containing basophilic hepatocytes. These were arranged as thickened tubules, solid round cellular masses and elongated, triangular-shaped cells forming irregular extensions (poorly differentiated tumor). Common cytologic features of tumor cells and cells of early altered foci (enzyme and tinctorial) suggested rapid neoplastic transformation of hepatocytes. The purpose of this study was to examine the ultrastructure of alterations occurring with development of hepatic neoplasms in O. latipes exposed to a tumorigenic concentration of DENA.
ISSN:0141-1136
1879-0291
DOI:10.1016/0141-1136(88)90326-1