School-Age Outcomes following a Randomized Controlled Trial of Magnesium Sulfate for Neuroprotection of Preterm Infants

In a French randomized trial, children at school-age demonstrated no evidence of harm from fetal exposure to MgSO4 before very preterm birth. Motor dysfunction/death, qualitative behavioral disorders, cognitive difficulties, school grade repetition, and education services were decreased in the child...

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Bibliographic Details
Published in:The Journal of pediatrics 2014-08, Vol.165 (2), p.398-400.e3
Main Authors: Chollat, Clément, MD, Enser, Maya, MD, Houivet, Estelle, MSc, Provost, Delphine, MD, Bénichou, Jacques, MD, PhD, Marpeau, Loïc, MD, Marret, Stéphane, MD, PhD
Format: Article
Language:English
Subjects:
Adolescent
Cerebral Palsy - prevention & control
Child
Female
Follow-Up Studies
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - prevention & control
Magnesium Sulfate - adverse effects
Magnesium Sulfate - therapeutic use
Male
Neuroprotective Agents - adverse effects
Neuroprotective Agents - therapeutic use
Pediatrics
Pregnancy
Prenatal Exposure Delayed Effects
Psychomotor Performance - drug effects
Psychomotor Performance - physiology
Surveys and Questionnaires
Treatment Outcome
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Summary:In a French randomized trial, children at school-age demonstrated no evidence of harm from fetal exposure to MgSO4 before very preterm birth. Motor dysfunction/death, qualitative behavioral disorders, cognitive difficulties, school grade repetition, and education services were decreased in the children exposed to MgSO4 , although the differences were not significant.
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2014.04.007