Triglyceride-lowering agents

[Display omitted] This review is the first attempt at systematization of the literature data on the structures and activities of triglyceride-lowering agents which used in medical practice or are in development. The effects and mechanisms of action of statins, squalene synthase inhibitors, fibrates,...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2014-07, Vol.22 (14), p.3551-3564
Main Authors: Salakhutdinov, Nariman F., Laev, Sergey S.
Format: Article
Language:English
Subjects:
Animals
Cholesterol - biosynthesis
Cholesterol - metabolism
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Enzymes - metabolism
Fibrates
Humans
Nicotinic acid
Omega-3 fatty acids
Peroxisome Proliferator-Activated Receptors - agonists
PPARα and PPARα/γ agonists
Squalene synthase inhibitors
Statins
Triglyceride-lowering agents
Triglycerides - chemistry
Triglycerides - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] This review is the first attempt at systematization of the literature data on the structures and activities of triglyceride-lowering agents which used in medical practice or are in development. The effects and mechanisms of action of statins, squalene synthase inhibitors, fibrates, PPARα and PPARα/γ agonists, nicotinic acid, omega-3 fatty acids and some other molecular targets were considered. Unfortunately, to date, harmless and effective triglyceride-lowering drug still does not exist and there is still need for development of better triglyceride-lowering agents.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2014.05.008