Comparative conformational studies of polypeptides containing a high percentage of proline

In the search for models of a proline-rich protein isolated from human parotid saliva the authors were led to synthesize and study H-(Gly-(Pro) sub(x)) sub(n)-OH (x = 3,4). Preliminary results concerning these polypeptides have already been reported and suggest that in aqueous solution these peptide...

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Bibliographic Details
Published in:Macromolecules 1981-05, Vol.14 (3), p.617-620
Main Authors: Helbecque, N, Loucheux-Lefebvre, M. H
Format: Article
Language:English
Subjects:
conformational analysis
proline-containing peptides
synthesis
Online Access:Get full text
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Summary:In the search for models of a proline-rich protein isolated from human parotid saliva the authors were led to synthesize and study H-(Gly-(Pro) sub(x)) sub(n)-OH (x = 3,4). Preliminary results concerning these polypeptides have already been reported and suggest that in aqueous solution these peptides adopt a polyproline II (PPII) conformation in addition to some other structures (probably unordered). In this paper the authors present a new synthesis of these products and a more complete conformational study comparing the relative stabilities of the PPII helix adopted by these polymers.
ISSN:0024-9297
1520-5835
DOI:10.1021/ma50004a032