Pancreas volume measurement in patients with Type 2 diabetes using magnetic resonance imaging-based planimetry

Abstract Background/objectives To compare pancreas volume (PV) measurement using MRI-based planimetry in patients with Type 2 diabetes mellitus (DM) to PV in normoglycemic individuals. Methods Our institutional review board granted approval of this retrospective study with waiver of informed consent...

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Published in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2014-07, Vol.14 (4), p.268-274
Main Authors: Burute, Nishigandha, Nisenbaum, Rosane, Jenkins, David J, Mirrahimi, Arash, Anthwal, Shalini, Colak, Errol, Kirpalani, Anish
Format: Article
Language:English
Subjects:
Abdomen
Adult
Age
Aged
Anatomy, Cross-Sectional
Blood Glucose - metabolism
Cohort Studies
Diabetes
Diabetes Mellitus, Type 2 - pathology
Endocrinology & Metabolism
Female
Gastroenterology and Hepatology
Humans
Imaging, Three-Dimensional
Long term health care
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medical imaging
Middle Aged
MRI
NMR
Nuclear magnetic resonance
Pancreas
Pancreas - pathology
Pancreas volume
Phantoms, Imaging
Planimetry
Retrospective Studies
Software packages
Studies
Type 2 diabetes mellitus
Ultrasonic imaging
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Summary:Abstract Background/objectives To compare pancreas volume (PV) measurement using MRI-based planimetry in patients with Type 2 diabetes mellitus (DM) to PV in normoglycemic individuals. Methods Our institutional review board granted approval of this retrospective study with waiver of informed consent. We searched 2296 consecutive abdominal MRI studies performed at our hospital on patients with no pancreas pathology between September 1, 2010 and February 28, 2013, for those who also had a fasting plasma glucose and/or hemoglobin A1C within six months of the MRI examination. For those patients who met biochemical criteria for DM, we used medication and clinical records to confirm that 32 of these patients had Type 2 DM. The pancreas contours of 32 Type 2 diabetics and 50 normoglycemic individuals were then traced on non-gadolinium T1-weighted 3D fat suppressed gradient echo images by a radiologist trained in abdominal MRI to calculate PV. PV index (PVI) was calculated as PV/weight to adjust PV for each patient's weight. PVs and PVIs in both cohorts were compared using t -tests and regression models correcting for weight, age and gender. Results Patients with Type 2 DM had significantly lower PVs than normoglycemic individuals (72.7 ± 20.7 cm3 versus 89.6 ± 22.7 cm3 , p  
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2014.04.031