Evidence for estradiol promotion of neoplastic lesions in the rat vagina after initiation with N-methyl-N-nitrosourea

The hypothesis that estrogens are tumor promoters was tested by tumor induction in the rat vagina. Ovariectomized rats were given a single dose of N-methyl-N-nitrosourea (MNU) by vaginal instillation, followed one week later by long-term release Silastic implants containing estradiol (E2). After 16...

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Bibliographic Details
Published in:Carcinogenesis (New York) 1982, Vol.3 (8), p.957-959
Main Authors: Sheehan, Daniel M., Frederick, Clay B., Branham, William S., Heath, James E.
Format: Article
Language:English
Subjects:
Animals
Castration
Estradiol - adverse effects
Female
Methylnitrosourea - toxicity
Neoplasms, Experimental - chemically induced
Nitrosourea Compounds - toxicity
Rats
Uterus - drug effects
Vaginal Neoplasms - chemically induced
Vaginal Neoplasms - pathology
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Summary:The hypothesis that estrogens are tumor promoters was tested by tumor induction in the rat vagina. Ovariectomized rats were given a single dose of N-methyl-N-nitrosourea (MNU) by vaginal instillation, followed one week later by long-term release Silastic implants containing estradiol (E2). After 16 months, a significant incidence (4/9) of benign vaginal stromal polyps was found in the MNU-E2 group, but no vaginal polyps were seen in groups given either MNU or E2 alone. A number of non-neoplastic changes were also seen and were due to E2 treatment either with or without MNU. The incidence of stromal polyps and their restriction to animals receiving the initiator-promoter regimen alone suggests that estrogens promote tumorigenesis in the rat vagina.
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/3.8.957