Induction of hepatic tumors with 7,12-dimethylbenz[ a]anthracene in two species of viviparous fishes (genus Poeciliopsis)

Liver neoplasms were induced in two species of viviparous fishes, Poeciliopsis lucida and P. monacha, by repeated short-term exposures to an aqueous suspension of 5 ppm 7,12-dimethylbenz[ a]anthracene (DMBA). Predominantly hepatocellular neoplasms developed in 47 out of 106 fish surviving the period...

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Published in:Environmental research 1982-04, Vol.27 (2), p.337-351
Main Authors: Schultz, Mary E., Schultz, R.Jack
Format: Article
Language:English
Subjects:
9,10-Dimethyl-1,2-benzanthracene - toxicity
Animals
Benz(a)Anthracenes - toxicity
Fishes - physiology
Freshwater
Liver - pathology
Liver Neoplasms - chemically induced
Liver Neoplasms - pathology
Neoplasms, Experimental - chemically induced
Neoplasms, Experimental - pathology
Poeciliopsis lucida
Poeciliopsis monacha
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Schultz, R.Jack
description Liver neoplasms were induced in two species of viviparous fishes, Poeciliopsis lucida and P. monacha, by repeated short-term exposures to an aqueous suspension of 5 ppm 7,12-dimethylbenz[ a]anthracene (DMBA). Predominantly hepatocellular neoplasms developed in 47 out of 106 fish surviving the period allowed for tumor development, 6–9 months after initial exposure to DMBA. The use of short-term exposure periods of 6 hr in young fish and up to 20 hr in adults reduced stress and mortalities caused by the toxicity of DMBA at 5 ppm. A lower concentration of DMBA, 0.25 ppm, failed to induce tumors in any of the surviving 230 of 295 young fish administered repeated 20-hr exposures. This study shows for the first time that DMBA is carcinogenic to fish.
doi_str_mv 10.1016/0013-9351(82)90089-5
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ispartof Environmental research, 1982-04, Vol.27 (2), p.337-351
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1096-0953
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source Backfile Package - Environmental Science (Legacy) [YES]
subjects 9,10-Dimethyl-1,2-benzanthracene - toxicity
Animals
Benz(a)Anthracenes - toxicity
Fishes - physiology
Freshwater
Liver - pathology
Liver Neoplasms - chemically induced
Liver Neoplasms - pathology
Neoplasms, Experimental - chemically induced
Neoplasms, Experimental - pathology
Poeciliopsis lucida
Poeciliopsis monacha
title Induction of hepatic tumors with 7,12-dimethylbenz[ a]anthracene in two species of viviparous fishes (genus Poeciliopsis)
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