Cross-Linked, Self-Fluorescent Gold Nanoparticle/Polypeptide Nanocapsules Comprising Dityrosine for Protein Encapsulation and Label-Free Imaging

Cross‐linked, self‐fluorescent Au nanoparticle/polypeptide nanocapsules comprising dityrosine are prepared by the self‐assembly of the random copolypeptides comprising L‐lysine and L‐tyrosine upon subsequent cross‐linking of tyrosine residues by chloroaurate reduction. These nanocapsules are demonst...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2014-05, Vol.10 (10), p.1939-1944
Main Authors: Huang, Yi-Fong, Lu, Sheing-Chung, Huang, Yun-Chiao, Jan, Jeng-Shiung
Format: Article
Language:English
Subjects:
cross-link
Cross-Linking Reagents - chemistry
Crosslinking
Diffusion
dityrosine
Encapsulation
Fluorescent Dyes - chemical synthesis
Gold
Gold - physiology
Imaging
label-free imaging
Materials Testing
Metal Nanoparticles - chemistry
Microscopy, Fluorescence - methods
Nanostructure
Nanotechnology
Peptides - chemistry
Polypeptides
Proteins
Self assembly
self-fluorescent
Staining and Labeling
Tyrosine - analogs & derivatives
Tyrosine - chemistry
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Summary:Cross‐linked, self‐fluorescent Au nanoparticle/polypeptide nanocapsules comprising dityrosine are prepared by the self‐assembly of the random copolypeptides comprising L‐lysine and L‐tyrosine upon subsequent cross‐linking of tyrosine residues by chloroaurate reduction. These nanocapsules are demonstrated be useful as encapsulants for protein encapsulation and as optical probes for label‐free cell imaging. The reduction process is so mild that the protein can still retain its function.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201303462