Bio-functionalized Pt nanoparticles based electrochemical impedance immunosensor for human cardiac myoglobin

We report the covalent immobilization of three-dimensional carboxyl-functionalized Pt(MPA) nanoparticles with myoglobin protein antibody by carbodiimide coupling reaction deposited onto an indium-tin-oxide-coated glass plate for the construction of a bioelectrode. This bioelectrode assembly was char...

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Bibliographic Details
Published in:RSC advances 2014-01, Vol.4 (41), p.21267-21276
Main Authors: Mishra, Sujeet K., Srivastava, Avanish K., Kumar, Devendra, Rajesh, Rajesh
Format: Article
Language:English
Subjects:
Antigens
Charge transfer
Human
Myoglobin
Nanoparticles
Phosphates
Silver
Three dimensional
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Summary:We report the covalent immobilization of three-dimensional carboxyl-functionalized Pt(MPA) nanoparticles with myoglobin protein antibody by carbodiimide coupling reaction deposited onto an indium-tin-oxide-coated glass plate for the construction of a bioelectrode. This bioelectrode assembly was characterized by spectro/microscopic and electrochemical techniques. Electrochemical impedance studies of the bioelectrode showed significant changes in charge transfer resistance ( R et ), predominantly in the low AC frequency region of
ISSN:2046-2069
2046-2069
DOI:10.1039/C4RA00105B