Electrochemical Detection of miRNAs

The recent progress made in the development of electrochemical methods for microRNA (miRNA) detection is presented. The progress is conceived to be largely due to the invention of novel assay methodologies and the use of various bioreagents and nanostructures. These enable a rigorous control over th...

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Bibliographic Details
Published in:Electroanalysis (New York, N.Y.) N.Y.), 2014-06, Vol.26 (6), p.1224-1235
Main Authors: Lautner, Gergely, Gyurcsányi, Róbert E.
Format: Article
Language:English
Subjects:
Amplification
Assaying
Concatamer
Detection
Diagnostic systems
Electrochemical detection
Electrolytic analysis
Impedance
Inventions
miRNA
Nanostructure
Peptide nucleic acid
Resistive pulse sensing
Ribonucleic acids
Voltammetry
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Summary:The recent progress made in the development of electrochemical methods for microRNA (miRNA) detection is presented. The progress is conceived to be largely due to the invention of novel assay methodologies and the use of various bioreagents and nanostructures. These enable a rigorous control over the sensing interface, provide enormous signal amplifications and single‐base mismatch specificity. Femtomolar or even subfemtomolar detection limits were shown to be feasible by electrochemical assays. Thus electrochemical detection methodologies are of perspective for diagnostic miRNA detection.
ISSN:1040-0397
1521-4109
DOI:10.1002/elan.201400055