Detection and Identification of Oestrogen-Active Substances in Plastic Food Packaging Migrates

Migrates from plastic food packaging were tested for oestrogen activity by yeast oestrogen screen and subsequently analysed by gas chromatography—mass spectrometry and high‐performance liquid chromatography—mass spectrometry to identify oestrogen‐active chemicals. Plastic samples were migrated accor...

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Bibliographic Details
Published in:Packaging technology & science 2014-06, Vol.27 (6), p.467-478
Main Authors: Kirchnawy, Christian, Mertl, Johannes, Osorio, Veronica, Hausensteiner, Helge, Washüttl, Michael, Bergmair, Johannes, Pyerin, Michael, Tacker, Manfred
Format: Article
Language:English
Subjects:
Chromatography
endocrine disruptors
Ethyl alcohol
Food packaging
GC/HPLC-MS
migration
Oestrogens
plastic food packaging
Polyethylene terephthalates
Spectrometry
Spectroscopy
Yeast
yeast oestrogen screen
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Summary:Migrates from plastic food packaging were tested for oestrogen activity by yeast oestrogen screen and subsequently analysed by gas chromatography—mass spectrometry and high‐performance liquid chromatography—mass spectrometry to identify oestrogen‐active chemicals. Plastic samples were migrated according to EC 10/2011 with worst case scenarios being used. Food simulants consisted of either 10–95% ethanol or ultrapure water. Migrates were concentrated afterwards by solid phase extraction. Food contact material tested included polyethylene terephthalate, polypropylene, polyethylene, polystyrene and composite films. Oestrogenic activity ranging from 0.7 to 59 ng/l 17ß‐estradiol equivalents was detected in seven out of 42 samples tested. The highest activity was found in a composite film sample. All 11 polyethylene terephthalate samples tested negative for oestrogen activity. A number of chemicals with known or supposed oestrogen activity were identified in migrates of oestrogen‐active samples. These include butylated hydroxytoluene, 1,3‐diphenylpropane, 1,2‐diphenylcyclobutane and dibutyl phthalate. Copyright © 2013 John Wiley & Sons, Ltd. Migrates from plastic food packaging were tested for oestrogen activity by yeast oestrogen screen and subsequently analysed by chromatographic methods to identify oestrogen‐active chemicals. Oestrogenic activity ranging from 0.7 to 59 ng/l 17β‐estradiol equivalents was detected in seven out of 42 samples tested. A number of chemicals with known or supposed oestrogen activity were identified in migrates of oestrogen‐active samples.
ISSN:0894-3214
1099-1522
DOI:10.1002/pts.2047