In vitro antibacterial activity of meclofenamate metal complexes with Cd(II), Pb(II), Co(II), and Cu(II). Crystal structures of [Cd(C14H10NO2Cl2)2∙(CH3OH)]n and [Cu(C14H10NO2Cl2)2(C5H5N)2]

• Published in: Journal of inorganic biochemistry 2014-10, Vol.139, p.85-92
• Main Authors: Palacios-Hernández, T., Höpfl, H., Sánchez-Salas, J.L., González-Vergara, E., Pérez-Benítez, A., Quiroz-Alfaro, M.A., Méndez-Rojas, M.A.
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial activity; Bacillus subtilis - drug effects; Cadmium; Cadmium - chemistry; Cobalt - chemistry; Complex; Coordination Complexes - chemistry; Coordination Complexes - pharmacology; Copper - chemistry; Crystallography, X-Ray; Escherichia coli - drug effects; Hydrogen Bonding; Hydrogen Peroxide - chemistry; Lead; Lead - chemistry; Meclofenamic; Meclofenamic Acid - analogs & derivatives; Meclofenamic Acid - chemistry; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Peroxidase activity; Pseudomonas aeruginosa - drug effects; Staphylococcus aureus - drug effects
• ISSN: 0162-0134; 1873-3344
• DOI: 10.1016/j.jinorgbio.2014.06.008

The synthesis and characterization of five metal complexes derived from sodium meclofenamate (1) are reported: [Cd(C14H10NO2Cl2)2∙(CH3OH)]n∙nCH3OH (6), [Pb(C14H10NO2Cl2)2]n (7), [Co(C14H10NO2Cl2)]n (8), [Cu(C14H10NO2Cl2)]n (9), and [Cu(C14H10NO2Cl2)2(C5H5N)2] (10) (C14H10NO2Cl2=meclofenamate; C5H5N=pyridine). The characterization of the compounds was based on FTIR and UV–visible spectroscopy, mass spectrometry and, in the case of complexes 6 and 10, single crystal X-ray diffraction analysis. For compound 6, the structural analysis revealed a 1-D polymeric chain structure, in which pentagonal planar [Cd(RCOO)2(CH3OH)] units were linked through bridging carboxylate functions of the meclofenamate ligands. The overall coordination environment of the Cd(II) ions was seven-coordinate, since each carboxylate group exhibited a μ3-bridging coordination mode. On the other hand, for complex 10 a discrete mononuclear structure was observed, in which the six-coordinate copper(II) metal atoms were coordinated by two pyridine molecules and the carboxylate functions of two meclofenamate entities, in an anisobidentate coordination mode. The antibacterial activity of compounds 6–9 against four strains of Gram positive (Staphylococcus aureus and Bacillus subtilis) and Gram negative (Escherichia coli and Pseudomonas aeruginosa) bacteria was examined, finding that only complex 6 was active. Additionally, it was found that the Co(II) and Cu(II) complexes 8 and 9 showed peroxidase activity. The synthesis and characterization of five metal complexes with sodium meclofenamate is reported. X-ray diffraction structures of two novel metal complexes [Cd(II) and Cu(II)] are described. Antibacterial activity of four metal-meclofenamate complexes [Cd(II), Pb(II), Co(II) and Cu(II)], as well as their peroxidase activity was evaluated. [Display omitted]