Interactions between Anticancer trans-Platinum Compounds and Proteins: Crystal Structures and ESI-MS Spectra of Two Protein Adducts of trans-(Dimethylamino)(methylamino)dichloridoplatinum(II)

The adducts formed between trans-(dimethylamino)(methylamino)dichloridoplatinum(II), [t-PtCl2(dma)(ma)], and two model proteins, i.e., hen egg white lysozyme and bovine pancreatic ribonuclease, were independently characterized by X-ray crystallography and electrospray ionization mass spectrometry. I...

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Bibliographic Details
Published in:Inorganic chemistry 2014-08, Vol.53 (15), p.7806-7808
Main Authors: Messori, Luigi, Marzo, Tiziano, Michelucci, Elena, Russo Krauss, Irene, Navarro-Ranninger, Carmen, Quiroga, Adoracion G, Merlino, Antonello
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Cattle
Crystallography, X-Ray
Muramidase - chemistry
Platinum Compounds - chemistry
Proteins - chemistry
Ribonuclease, Pancreatic - chemistry
Spectrometry, Mass, Electrospray Ionization
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Summary:The adducts formed between trans-(dimethylamino)(methylamino)dichloridoplatinum(II), [t-PtCl2(dma)(ma)], and two model proteins, i.e., hen egg white lysozyme and bovine pancreatic ribonuclease, were independently characterized by X-ray crystallography and electrospray ionization mass spectrometry. In these adducts, the PtII center, upon chloride release, coordinates either to histidine or aspartic acid residues while both alkylamino ligands remain bound to the metal. Comparison with the cisplatin derivatives of the same proteins highlights for [t-PtCl2(dma)(ma)] a kind of biomolecular metalation remarkably different from that of cisplatin.
ISSN:0020-1669
1520-510X
DOI:10.1021/ic5012583