Beam-specific planning volumes for scattered-proton lung radiotherapy

• Published in: Physics in medicine & biology 2014-08, Vol.59 (16), p.4549-4566
• Main Authors: Flampouri, S, Hoppe, B S, Slopsema, R L, Li, Z
• Format: Article
• Language: English
• Subjects: Humans; lung; Lung Neoplasms - radiotherapy; Organs at Risk - radiation effects; Proton Therapy - adverse effects; Proton Therapy - methods; proton treatment planning; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted - methods; uncertainties
• ISSN: 0031-9155; 1361-6560
• DOI: 10.1088/0031-9155/59/16/4549

This work describes the clinical implementation of a beam-specific planning treatment volume (bsPTV) calculation for lung cancer proton therapy and its integration into the treatment planning process. Uncertainties incorporated in the calculation of the bsPTV included setup errors, machine delivery variability, breathing effects, inherent proton range uncertainties and combinations of the above. Margins were added for translational and rotational setup errors and breathing motion variability during the course of treatment as well as for their effect on proton range of each treatment field. The effect of breathing motion and deformation on the proton range was calculated from 4D computed tomography data. Range uncertainties were considered taking into account the individual voxel HU uncertainty along each proton beamlet. Beam-specific treatment volumes generated for 12 patients were used: a) as planning targets, b) for routine plan evaluation, c) to aid beam angle selection and d) to create beam-specific margins for organs at risk to insure sparing. The alternative planning technique based on the bsPTVs produced similar target coverage as the conventional proton plans while better sparing the surrounding tissues. Conventional proton plans were evaluated by comparing the dose distributions per beam with the corresponding bsPTV. The bsPTV volume as a function of beam angle revealed some unexpected sources of uncertainty and could help the planner choose more robust beams. Beam-specific planning volume for the spinal cord was used for dose distribution shaping to ensure organ sparing laterally and distally to the beam.