Changes in neural stem cells in the subventricular zone in a rat model of communicating hydrocephalus

•Changes in NSCs in the SVZ caused by hydrocephalus and x-rays are not identical.•Symptoms of hydrocephalus in different stages were consistent with changes of NSCs.•Provide research direction on the mechanism of the function of NSCs in hydrocephalus.•Provide a theoretical basis on the NSCs in the t...

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Bibliographic Details
Published in:Neuroscience letters 2014-08, Vol.578, p.153-158
Main Authors: Li, Yan, Wu, Dongxue, Wu, Chunming, Qu, Zhenyun, Zhao, Yongshun, Li, Weihua, Wang, Jian, Li, Zhongmin
Format: Article
Language:English
Subjects:
Animals
Cell Proliferation
Communicating hydrocephalus
Disease Models, Animal
Female
Hydrocephalus - physiopathology
Lateral Ventricles - pathology
Lateral Ventricles - physiopathology
Male
Neural stem cells
Neural Stem Cells - physiology
Rats
Rats, Wistar
Shunt
Ventricular-subventricular zone
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Summary:•Changes in NSCs in the SVZ caused by hydrocephalus and x-rays are not identical.•Symptoms of hydrocephalus in different stages were consistent with changes of NSCs.•Provide research direction on the mechanism of the function of NSCs in hydrocephalus.•Provide a theoretical basis on the NSCs in the treatment of hydrocephalus. Communicating hydrocephalus is a common type of hydrocephalus. At present, the prevalent treatment is to perform a ventriculo-peritoneal shunt, which, for reasons that are not clear, is sometimes ineffective. The subventricular zone (SVZ) of the lateral ventricles has been established as the primary site of adult neurogenesis. Following cerebral ischemia or brain injury, neural stem cells (NSCs) increase in the SVZ and can both differentiate into neurons and glial cells and respond to the injury. Neural stem cells, enabled by a complex repertoire of factors that precisely regulate the activation, proliferation, differentiation and integration of newborn cells, continuously generate new neurons. However, only a few systematic studies of the role of NSCs in hydrocephalus have been reported. In a rat model of communicating hydrocephalus, we recently showed that hydrocephalus caused the ventricular system to expand over time. We found that the number of NSCs in the SVZ peaked rapidly after hydrocephalus was established and decreased gradually over time until the cells disappeared. NSCs may be involved in the pathophysiology changes and repair process of hydrocephalus.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2014.06.053