Lipopolysaccharide-activated dendritic cells: "exhausted" or alert and waiting?

LPS-activated dendritic cells (DCs) are thought to follow a set program in which they secrete inflammatory cytokines (such as IL-12) and then become refractory to further stimulation (i.e., "exhausted"). In this study, we show that mouse DCs do indeed lose their responsiveness to LPS, but...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2012-06, Vol.188 (12), p.5981-5989
Main Authors: Abdi, Kaveh, Singh, Nevil J, Matzinger, Polly
Format: Article
Language:English
Subjects:
Animals
Cell Communication - immunology
Cell Differentiation - immunology
Coculture Techniques
Cytokines - biosynthesis
Dendritic Cells - cytology
Dendritic Cells - immunology
Enzyme-Linked Immunosorbent Assay
Female
Lipopolysaccharides - immunology
Lymphocyte Activation - immunology
Male
Mice
Mice, Knockout
Mice, Transgenic
T-Lymphocytes - cytology
T-Lymphocytes - immunology
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Summary:LPS-activated dendritic cells (DCs) are thought to follow a set program in which they secrete inflammatory cytokines (such as IL-12) and then become refractory to further stimulation (i.e., "exhausted"). In this study, we show that mouse DCs do indeed lose their responsiveness to LPS, but nevertheless remain perfectly capable of making inflammatory cytokines in response to signals from activated T cells and to CD40-ligand and soluble T cell-derived signals. Furthermore, far from being rigidly programmed by the original activating stimulus, the DCs retained sufficient plasticity to respond differentially to interactions with Th0, Th1, Th2, and Th17 T cells. These data suggest that LPS activation does not exhaust DCs but rather primes them for subsequent signals from T cells.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.1102868