Emergence of pneumococcal 19A empyema in UK children

Introduction Invasive pneumococcal disease due to serotype 19A has become a major concern, particularly in the USA and Asia. We describe the characteristics of pneumococcal serotype 19A related empyema and changes in its incidence in the UK. Methods Data from paediatric empyema patients between Sept...

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Bibliographic Details
Published in:Archives of disease in childhood 2012-12, Vol.97 (12), p.1070-1072
Main Authors: Thomas, Matthew F, Sheppard, Carmen L, Guiver, Malcolm, Slack, Mary P E, George, Robert C, Gorton, Russell, Paton, James Y, Simmister, Clare, Cliff, David, Elemraid, Mohamed A, Clark, Julia E, Rushton, Stephen P, Spencer, David Anthony
Format: Article
Language:English
Subjects:
Adolescent
Age
Antibiotics
Biological and medical sciences
Child
Child, Preschool
Children & youth
Comorbidity
Company distribution practices
Distribution
Drug resistance
Empyema
Empyema - epidemiology
Empyema - microbiology
Epidemiology
Female
General aspects
Hospitals
Humans
Immunisation
Incidence
Infant
Infant, Newborn
Infectious Diseases
Intensive care
Male
Medical sciences
Miscellaneous
Patients
Pneumococcal infections
Pneumococcal Infections - epidemiology
Pneumonia
Prevention and actions
Public health. Hygiene
Public health. Hygiene-occupational medicine
Respiratory
Serotyping
Statistical Analysis
Streptococcus infections
Streptococcus pneumoniae
Streptococcus pneumoniae - classification
Surveillance
United Kingdom - epidemiology
Vaccines
Ventilation
Citations: Items that cite this one
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Summary:Introduction Invasive pneumococcal disease due to serotype 19A has become a major concern, particularly in the USA and Asia. We describe the characteristics of pneumococcal serotype 19A related empyema and changes in its incidence in the UK. Methods Data from paediatric empyema patients between September 2006 and March 2011 were collected from 17 respiratory centres in the UK. Pneumococcal serotypes were identified as part of the Health Protection Agency enhanced paediatric empyema surveillance programme. Results Four serotypes accounted for over 80% of 136 cases (Serotype 1 : 43%, 3 : 21%, 7 : 11% and 19A:10%). The incidence of empyema due to serotype 19A quadrupled from 0.48 (0.16–1.13) cases per million children in 2006/2007 to 2.02 (1.25–3.09) in 2010/2011. Severity of disease was significantly increased in children with 19A infection when compared to other serotypes. Conclusions The incidence of empyema due to pneumococcal serotype 19A infection has increased significantly and is associated with substantial morbidity.
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2012-301790