Molecular phylogeography of tick-borne encephalitis virus in central Europe

In order to obtain a better understanding of tick-borne encephalitis virus (TBEV) strain movements in central Europe the E gene sequences of 102 TBEV strains collected from 1953 to 2011 at 38 sites in the Czech Republic, Slovakia, Austria and Germany were determined. Bayesian analysis suggests a 350...

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Bibliographic Details
Published in:Journal of general virology 2013-09, Vol.94 (Pt 9), p.2129-2139
Main Authors: Weidmann, Manfred, Frey, Stefan, Freire, Caio C M, Essbauer, Sandra, Růžek, Daniel, Klempa, Boris, Zubrikova, Dana, Vögerl, Maria, Pfeffer, Martin, Hufert, Frank T, Zanotto, Paolo M, Dobler, Gerhard
Format: Article
Language:English
Subjects:
Animals
Cluster Analysis
Encephalitis Viruses, Tick-Borne - classification
Encephalitis Viruses, Tick-Borne - genetics
Encephalitis Viruses, Tick-Borne - isolation & purification
Europe
Genotype
Mammals - virology
Molecular Epidemiology
Molecular Sequence Data
Phylogeography
Sequence Analysis, DNA
Tick-borne encephalitis virus
Ticks - virology
Viral Envelope Proteins - genetics
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Summary:In order to obtain a better understanding of tick-borne encephalitis virus (TBEV) strain movements in central Europe the E gene sequences of 102 TBEV strains collected from 1953 to 2011 at 38 sites in the Czech Republic, Slovakia, Austria and Germany were determined. Bayesian analysis suggests a 350-year history of evolution and spread in central Europe of two main lineages, A and B. In contrast to the east to west spread at the Eurasian continent level, local central European spreading patterns suggest historic west to east spread followed by more recent east to west spread. The phylogenetic and network analyses indicate TBEV ingressions from the Czech Republic and Slovakia into Germany via landscape features (Danube river system), biogenic factors (birds, red deer) and anthropogenic factors. The identification of endemic foci showing local genetic diversity is of paramount importance to the field as these will be a prerequisite for in-depth analysis of focal TBEV maintenance and long-distance TBEV spread.
ISSN:0022-1317
1465-2099
1465-2099
DOI:10.1099/vir.0.054478-0