Synthesis of a novel acrylated abietic acid-g-bacterial cellulose hydrogel by gamma irradiation

Acrylated abietic acid (acrylated AbA) and acrylated abietic acid-grafted bacterial cellulose pH sensitive hydrogel (acrylated AbA-g-BC) were prepared by a one-pot synthesis. The successful dimerization of acrylic acid (AA) and abietic acid (AbA) and grafting of the dimer onto bacterial cellulose (B...

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Bibliographic Details
Published in:Carbohydrate polymers 2014-09, Vol.110, p.505-512
Main Authors: MUHAMMAD MUSTAFA ABEER, MOHD CAIRUL IQBAL MOHD AMIN, AZWAN MAT LAZIM, PANDEY, Manisha, MARTIN, Claire
Format: Article
Language:English
Subjects:
Acetobacter - chemistry
Acrylates - chemical synthesis
Acrylates - chemistry
Animals
Applied sciences
Cell Line
Cell Survival
Cellulose - analogs & derivatives
Cellulose - chemical synthesis
Cocos - microbiology
Cricetinae
Dimerization
Diterpenes, Abietane - chemical synthesis
Diterpenes, Abietane - chemistry
Drug Delivery Systems
Exact sciences and technology
Food Microbiology
Gamma Rays
Grafting and modifications
Hydrogel, Polyethylene Glycol Dimethacrylate - chemical synthesis
Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry
Physicochemistry of polymers
Polymers and radiations
Polysaccharides, Bacterial - chemical synthesis
Polysaccharides, Bacterial - chemistry
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Summary:Acrylated abietic acid (acrylated AbA) and acrylated abietic acid-grafted bacterial cellulose pH sensitive hydrogel (acrylated AbA-g-BC) were prepared by a one-pot synthesis. The successful dimerization of acrylic acid (AA) and abietic acid (AbA) and grafting of the dimer onto bacterial cellulose (BC) was confirmed by 13C solid state NMR as well as FT-IR. X-ray diffraction analysis showed characteristic peaks for AbA and BC; further, there was no effect of increasing amorphous AA content on the overall crystallinity of the hydrogel. Differential scanning calorimetry revealed a glass transition temperature of 80°C. Gel fraction and swelling studies gave insight into the features of the hydrogel, suggesting that it was suitable for future applications such as drug delivery. Scanning electron microscopy observations showed an interesting interpenetrating network within the walls of hydrogel samples with the lowest levels of AA and gamma radiation doses. Cell viability test revealed that the synthesized hydrogel is safe for future use in biomedical applications.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2014.04.052