Lower Helicobacter pylori infection rate in chronic kidney disease and end-stage renal disease patients with peptic ulcer disease

Abstract Background Distinguishing the rates of Helicobacter pylori infection in chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients with peptic ulcer disease (PUD) from that in PUD patients without CKD is critical. Methods We first stratified the original 1 million study popula...

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Bibliographic Details
Published in:Journal of the Chinese Medical Association 2014-07, Vol.77 (7), p.354-359
Main Authors: Chang, Shen-Shong, Hu, Hsiao-Yun
Format: Article
Language:English
Subjects:
Adult
chronic kidney disease
end-stage renal disease
Female
H. pylori
Helicobacter Infections - complications
Helicobacter Infections - epidemiology
Helicobacter pylori
Humans
Internal Medicine
Kidney Failure, Chronic - complications
lower
Male
Middle Aged
Peptic Ulcer - complications
peptic ulcers
Regression Analysis
Renal Insufficiency, Chronic - complications
Retrospective Studies
Taiwan - epidemiology
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Summary:Abstract Background Distinguishing the rates of Helicobacter pylori infection in chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients with peptic ulcer disease (PUD) from that in PUD patients without CKD is critical. Methods We first stratified the original 1 million study population according to CKD or ESRD. We retrospectively investigated the incidence of H. pylori infection in PUD patients with or without CKD or ESRD between 2000 and 2008 in a nationwide, population-based cohort using data from the Taiwan National Health Insurance Research Database. The comparison cohort consisted of PUD patients without CKD. A logistic regression model was used to calculate the odds ratios (ORs) and 95% confidence intervals, to determine whether the occurrence of H. pylori infection in CKD or ESRD patients with PUD differed from that of PUD patients without CKD. Results Among the CKD patients, 261 patients had H. pylori -positive and 185 H. pylori -negative peptic ulcers. Among the ESRD patients, 81 had H. pylori -positive and 63 H. pylori -negative peptic ulcers. Among the non-CKD control patients, 1658 patients had H. pylori -positive and 702 H. pylori -negative peptic ulcers. Our results revealed a lower H. pylori infection rate in CKD (OR = 0.64, p  
ISSN:1726-4901
1728-7731
DOI:10.1016/j.jcma.2014.04.004