Polybrominated biphenyls as promoters in experimental hepatocarcinogenesis in rats

Female Sprague Dawley rats were fed polybrominated biphenyls (PBB) for six months after a 70% partial hepatectomy and diethylnitrosamine administration (10 mg/kg body weight) to determine if PBB could serve as a tumor promoter in a two stage hepatocarcinogenesis test system. Firemaster BP-6, a comme...

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Bibliographic Details
Published in:Carcinogenesis (New York) 1982, Vol.3 (10), p.1183-1186
Main Authors: Jensen, Richard K., Sleight, Stuart D., Goodman, Jay I., Aust, Steven D., Trosko, James E.
Format: Article
Language:English
Subjects:
Acyltransferases - metabolism
Animals
Biphenyl Compounds - pharmacology
Carcinogens
Diethylnitrosamine
Female
Liver - drug effects
Liver - enzymology
Liver Neoplasms - chemically induced
Neoplasms, Experimental - chemically induced
Phenobarbital - pharmacology
Polybrominated Biphenyls - pharmacology
Rats
Rats, Inbred Strains
Transglutaminases
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Summary:Female Sprague Dawley rats were fed polybrominated biphenyls (PBB) for six months after a 70% partial hepatectomy and diethylnitrosamine administration (10 mg/kg body weight) to determine if PBB could serve as a tumor promoter in a two stage hepatocarcinogenesis test system. Firemaster BP-6, a commercial mixture of PBB, and its major congener, 2,2',4,4',5,5' -hexabromobiphenyl (HBB) were used in this study. Tumor promoting ability was assessed by measuring enzyme altered foci exhibiting gamma glutamyl transpeptidase activity. Dietary concentrations of 10 and 100 p.p.m. of the mixture of PBB and of HBB were found to be promoters of hepatocarcinogenesis. The mixture of PBB had a greater tumor promoting ability than HBB.
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/3.10.1183