Pathological remodeling of myocardium in spontaneous hypertensive rats with experimental diabetes mellitus: the role of mitochondrial dysfunction

The expression of cardiotrophin-1, annexin V, titin and type I collagen was investigated in myocardium of normotensive Wistar rats and spontaneous hypertensive rats with and without experimental diabetes. The Ca(2+)-induced mitochondrial permeability transition pore was assessed in mitochondria isol...

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Bibliographic Details
Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2014, Vol.60 (3), p.18-26
Main Authors: Kolesnyk, Iu M, Kolesnyk, M Iu, Abramov, A V
Format: Article
Language:eng ; ukr
Subjects:
Animals
Annexin A5 - genetics
Annexin A5 - metabolism
Calcium - metabolism
Collagen Type I - genetics
Collagen Type I - metabolism
Connectin - genetics
Connectin - metabolism
Cytokines - genetics
Cytokines - metabolism
Diabetes Mellitus, Experimental - complications
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Experimental - metabolism
Diabetes Mellitus, Experimental - pathology
Gene Expression
Hypertension - complications
Hypertension - drug therapy
Hypertension - metabolism
Hypertension - pathology
Male
Mitochondria, Heart - metabolism
Mitochondria, Heart - pathology
Mitochondrial Membrane Transport Proteins - genetics
Mitochondrial Membrane Transport Proteins - metabolism
Myocardium - metabolism
Myocardium - pathology
Rats
Rats, Inbred SHR
Rats, Wistar
Ventricular Remodeling
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Summary:The expression of cardiotrophin-1, annexin V, titin and type I collagen was investigated in myocardium of normotensive Wistar rats and spontaneous hypertensive rats with and without experimental diabetes. The Ca(2+)-induced mitochondrial permeability transition pore was assessed in mitochondria isolated from rat hearts. The contents of cardiotrophin-1, annexin V and type I collagen in spontaneous hypertensive rats with diabetes were higher compared with that detected in the groups of normotensive rats and rats with diabetes. The cardiac titin level was 27% lower in animals with hypertension and diabetes compared to spontaneous hypertensive rats without diabetes. The changes of cardiotrophin-1, annexin V, titin and type I collagen expression were associated with higher sensitivity of mitochondrial pore to Ca2+ in myocardium of spontaneous hypertensive rats with diabetes.
ISSN:2522-9028
2522-9036
DOI:10.15407/fz60.03.018