On the response of mouse peritoneal macrophages to titanium dioxide pigments in vitro

Acid phosphatase activity and cell morphology were followed using mouse peritoneal macrophages as a toxicity test model in vitro. The cells were given titanium dioxide (TiO 2) and five titanium pigments with different coating materials in 100 μg/ml of culture medium. The cell reactions were studied...

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Bibliographic Details
Published in:Environmental research 1982-10, Vol.29 (1), p.174-184
Main Authors: Nuuja, Ismo J.M., Arstila, Antti U.
Format: Article
Language:English
Subjects:
Acid Phosphatase - metabolism
Animals
Ascitic Fluid - cytology
Cells, Cultured
Coloring Agents - toxicity
Macrophages - drug effects
Macrophages - enzymology
Macrophages - ultrastructure
Male
Mice
Titanium - toxicity
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Summary:Acid phosphatase activity and cell morphology were followed using mouse peritoneal macrophages as a toxicity test model in vitro. The cells were given titanium dioxide (TiO 2) and five titanium pigments with different coating materials in 100 μg/ml of culture medium. The cell reactions were studied from 1 to 17 days. Titanium particles inhibited the acid phosphatase activity of the cells compared to controls. In comparison to untreated cells the activity of this enzyme increased in most groups studied, being highest in the control cells (2–3.5 times) after 7 days. The titanium pigments did not cause the drastic alterations in these cells as seen with quartz and asbestos particles, but the titanium pigments were not harmless to the mouse peritoneal macrophages with the doses and culture times used.
ISSN:0013-9351
1096-0953
DOI:10.1016/0013-9351(82)90017-2