Effects of modified Lingguizhugan decoction combined with weekend fasting on metabolic syndrome

• Published in: Journal of traditional Chinese medicine 2014-02, Vol.34 (1), p.48-51
• Main Authors: Yang, Yubin, Li, Qiong, Chen, Shuqing, Ke, Bin, Huang, Yinjuan, Qin, Jian
• Format: Article
• Language: English
• Subjects: Adult; Aged; Blood Glucose - metabolism; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Drugs, Chinese Herbal - administration & dosage; Fasting - metabolism; Female; HDL-C; Humans; Male; Metabolic Syndrome - drug therapy; Metabolic Syndrome - metabolism; Metabolic Syndrome - physiopathology; Middle Aged; 代谢综合征; 修改; 冠状动脉粥样硬化; 治疗效果; 禁食; 空腹血糖; 胰岛素抵抗
• ISSN: 0255-2922
• DOI: 10.1016/S0254-6272(14)60053-4

OBJECTIVE： To assess the therapeutic effect of weekend fasting and administration of a modified Lingguizhugan decoction on metabolic syndrome（MetS）. METHODS： Twenty-one patients with MetS were recruited from the First Affiliated Hospital of Sun Yat-Sen University. Fasting plasma glucose（FPG）, 30-min and 2-h post-prandial blood glucose（PG）, fasting serum insulin（FINS）, blood pressure（BP）, body mass index（BMI）, waist circumference（WC）, homeostasis model assessment for insulin resis- tance index（HOMA-IR）, and levels of triglyceride（TG）, total cholesterol（TC）, low-density lipopro- tein-cholesterol（LDL-C）, and high-density lipopro- tein cholesterol（HDL-C） were tested. Patients were allowed to drink only water and a Chinese herbal decoction during weekends. All samples were test- ed again after 12 weeks of treatment. RESULTS： FPG, 30-min PG, 2-h PG, FINS, LDL-C, sys- tolic BP, diastolic BP, BMI, WC, and HOMA-IR de-creased significantly（P0.05） compared with be- fore treatment. Levels of TG, TC, and HDL-C did not change significantly. CONCLUSION： Weekend fasting improved glucose metabolism, lowered BP, reduced LDL-C levels, BMI, and WC. These data suggest that weekend fasting may be an effective therapy for MetS by protection against coronary atherosclerosis.