Assessing Therapy Response of Secreting Pineal Germ Cell Tumor on Simultaneous 18F-Choline PET/MRI

ABSTRACTAn 18-year-old man presented with 6 weeks’ history of diplopia, early morning headaches, and blurred vision; on ophthalmologic examination, Parinaud syndrome was revealed. Brain MRI scan showed a calcified pineal mass. Brain simultaneous PET/MRI with F-choline showed an avid enhancing mass o...

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Bibliographic Details
Published in:Clinical nuclear medicine 2014-09, Vol.39 (9), p.e387-e388
Main Authors: Panagiotidis, Emmanouil, Shankar, Ananth, Afaq, Asim, Bomanji, Jamshed
Format: Article
Language:English
Subjects:
Adolescent
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - drug therapy
Brain Neoplasms - pathology
Choline - analogs & derivatives
Cisplatin - therapeutic use
Cyclophosphamide - therapeutic use
Etoposide - therapeutic use
Humans
Magnetic Resonance Imaging
Male
Multimodal Imaging
Neoplasms, Germ Cell and Embryonal - diagnostic imaging
Neoplasms, Germ Cell and Embryonal - drug therapy
Neoplasms, Germ Cell and Embryonal - pathology
Pineal Gland - diagnostic imaging
Pineal Gland - pathology
Pinealoma - diagnostic imaging
Pinealoma - drug therapy
Pinealoma - pathology
Positron-Emission Tomography
Radiopharmaceuticals
Treatment Outcome
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Summary:ABSTRACTAn 18-year-old man presented with 6 weeks’ history of diplopia, early morning headaches, and blurred vision; on ophthalmologic examination, Parinaud syndrome was revealed. Brain MRI scan showed a calcified pineal mass. Brain simultaneous PET/MRI with F-choline showed an avid enhancing mass occupying the pineal region with restricted diffusion. A second examination after chemotherapy demonstrated reduction in both size and radiotracer activity of the mass. Our study emphasizes the potential of simultaneous F-choline PET/MRI being a useful tool for contribution in the diagnosis and treatment assessment in a convenient way with minimal radiation exposure and reduced throughput patient time.
ISSN:0363-9762
1536-0229
DOI:10.1097/RLU.0000000000000231