Seeking help: B cells adapting to flu variability

The study of influenza vaccines has revealed potential interactions between preexisting immunological memory and antigenic context and/or adjuvantation. In the face of antigenic diversity, the process of generating B cell adaptability is driven by cross-reactive CD4 memory cells, such as T follicula...

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Bibliographic Details
Published in:Science translational medicine 2014-07, Vol.6 (246), p.246ps8-246ps8
Main Authors: van der Most, Robbert G, Roman, François P, Innis, Bruce, Hanon, Emmanuel, Vaughn, David W, Gillard, Paul, Walravens, Karl, Wettendorff, Martine
Format: Article
Language:English
Subjects:
Adaptation, Physiological - immunology
Adjuvants, Immunologic
B-Lymphocytes - immunology
Hemagglutinin Glycoproteins, Influenza Virus - immunology
Humans
Influenza Vaccines - immunology
Influenza, Human - immunology
T-Lymphocytes, Helper-Inducer - immunology
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Summary:The study of influenza vaccines has revealed potential interactions between preexisting immunological memory and antigenic context and/or adjuvantation. In the face of antigenic diversity, the process of generating B cell adaptability is driven by cross-reactive CD4 memory cells, such as T follicular helper cells from previous infections or vaccinations. Although such "helped" B cells are capable of adapting to variant antigens, lack of CD4 help could lead to a suboptimal antibody response. Collectively, this indicates an interplay between CD4 T cells, adjuvant, and B cell adaptability.
ISSN:1946-6234
1946-6242
DOI:10.1126/scitranslmed.3008409