Prognosis of patients with alpha1 -antitrypsine deficiency on long-term oxygen therapy

Summary Introduction Data on patients with alpha1 -antitrypsine deficiency (AATD) on long-term oxygen therapy (LTOT) is sparse. The aim of this study was to present the incidence of patients with AATD on LTOT, and compare their characteristics, comorbidities and prognosis (lung transplantation, term...

Full description

Saved in:
Bibliographic Details
Published in:Respiratory medicine 2014-08, Vol.108 (8), p.1189-1194
Main Authors: Ringbaek, Thomas J, Seersholm, Niels, Perch, Michael, Iversen, Martin, Lange, Peter
Format: Article
Language:English
Subjects:
Age
alpha 1-Antitrypsin Deficiency - complications
alpha 1-Antitrypsin Deficiency - mortality
Alpha1-antitrypsine deficiency
Cardiovascular Diseases - complications
Cardiovascular Diseases - mortality
Confidence intervals
COPD
Diabetes
Diabetes Complications - complications
Diabetes Complications - mortality
Disease
Female
Genotype & phenotype
Heart failure
Humans
Long-Term Care
LTOT
Lung Transplantation - mortality
Male
Medical prognosis
Middle Aged
Multivariate analysis
Osteoporosis
Osteoporosis - complications
Osteoporosis - mortality
Oxygen - therapeutic use
Oxygen therapy
Patients
Prognosis
Prospective Studies
Pulmonary Disease, Chronic Obstructive - complications
Pulmonary Disease, Chronic Obstructive - mortality
Pulmonary Disease, Chronic Obstructive - therapy
Pulmonary/Respiratory
Ratios
Regression analysis
Sex Factors
Survival
Transplants & implants
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Introduction Data on patients with alpha1 -antitrypsine deficiency (AATD) on long-term oxygen therapy (LTOT) is sparse. The aim of this study was to present the incidence of patients with AATD on LTOT, and compare their characteristics, comorbidities and prognosis (lung transplantation, termination of LTOT, and survival) with COPD patients without AATD. Methods A National prospective study of all COPD patients who started LTOT for the first time in the period 01.11.1994 to 31.12.2010. Results Among the 21,964 patients on LTOT, 234 patients had AATD. AATD patients were more often males and were on average about 17 years younger than patients without AATD. Cardio-vascular diseases and diabetes mellitus were significantly less prevalent among patients with AATD (60.4% versus 70.3% ( P  
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2014.05.001