Deterioration of the circadian variation of heart rate variability in Brugada syndrome may contribute to the pathogenesis of ventricular fibrillation

Abstract Aims Abnormal sympathetic innervation triggers ventricular fibrillation (VF). We examined the circadian variation of autonomic nervous system and its relevance to risk stratification of VF in patients with Brugada syndrome (Brs). Methods We enrolled 12 male Brs patients with documented VF (...

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Bibliographic Details
Published in:Journal of cardiology 2014-08, Vol.64 (2), p.133-138
Main Authors: Tokuyama, Takehito, MD, Nakano, Yukiko, MD, PhD, FJCC, Awazu, Akinori, PhD, Uchimura-Makita, Yuko, MD, Fujiwra, Mai, MD, Watanabe, Yoshikazu, MD, Sairaku, Akinori, MD, Kajihara, Kenta, MD, Motoda, Chikaaki, MD, Oda, Noboru, MD, PhD, Kihara, Yasuki, MD, PhD, FJCC
Format: Article
Language:English
Subjects:
Adult
Autonomic nervous system
Autonomic Nervous System - physiopathology
Brugada Syndrome - complications
Brugada Syndrome - diagnosis
Brugada Syndrome - physiopathology
Cardiovascular
Circadian rhythm
Circadian Rhythm - physiology
Electrocardiography - methods
Heart Rate - physiology
Humans
Male
Middle Aged
Sensitivity and Specificity
Ventricular fibrillation
Ventricular Fibrillation - diagnosis
Ventricular Fibrillation - etiology
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Summary:Abstract Aims Abnormal sympathetic innervation triggers ventricular fibrillation (VF). We examined the circadian variation of autonomic nervous system and its relevance to risk stratification of VF in patients with Brugada syndrome (Brs). Methods We enrolled 12 male Brs patients with documented VF (Brs-S; mean age, 42 ± 4 years), 17 without documented VF (Brs-N; mean age 48 ± 4 years), and 16 age- and gender-matched controls. The clinical data, 12-lead electrocardiography (ECG), signal-averaged ECG, electrophysiological study (EPS), and heart rate variability from 24 h Holter ECG were compared between the groups. Results The low frequency components (LF) in Brs-S and Brs-N and high frequency components (HF) in Brs-S patients were significantly lower than in the controls (409.8 ± 128.6 ms2 , 329.5 ± 108 ms2 vs. 945.3 ± 111.3 ms2 ; 135.1 ± 73.8 ms2 vs. 391.8 ± 63.9 ms2 , respectively). The circadian variation of the LF and LF/HF decreased in the Brs patients, the standard deviation (SD) of LF/HF (
ISSN:0914-5087
1876-4738
DOI:10.1016/j.jjcc.2013.12.001