Association of hip and pelvic geometry with tibiofemoral osteoarthritis: Multicenter Osteoarthritis Study (MOST)

• Published in: Osteoarthritis and cartilage 2014-08, Vol.22 (8), p.1129-1135
• Main Authors: Boissonneault, A, Lynch, J.A, Wise, B.L, Segal, N.A, Gross, K.D, Murray, D.W, Nevitt, M.C, Pandit, H.G
• Format: Article
• Language: English
• Subjects: Aged; Biomechanics; Bone Malalignment - diagnostic imaging; Bone Malalignment - epidemiology; Case-Control Studies; Female; Femur - diagnostic imaging; Hip geometry; Hip Joint - diagnostic imaging; Humans; Knee alignment; Knee Joint - diagnostic imaging; Knee osteoarthritis; Male; Middle Aged; Osteoarthritis, Knee - diagnostic imaging; Osteoarthritis, Knee - epidemiology; Pelvic Bones - diagnostic imaging; Radiography; Rheumatology; Sex Characteristics; Sex Factors; Tibia - diagnostic imaging
• ISSN: 1063-4584; 1522-9653
• DOI: 10.1016/j.joca.2014.06.010

Summary Objective Lateral tibiofemoral osteoarthritis (OA) is overall less common than medial tibiofemoral OA, but it is more prevalent in women. This may be explained by sex differences in hip and pelvic geometry. The aim of this study is to explore sex differences in hip and pelvic geometry and determine if such parameters are associated with the presence of compartment-specific knee OA. Methods This case-control study reports on 1,328 hips/knees from 664 participants and is an ancillary to the Multicenter Osteoarthritis Study (MOST). Of the 1,328 knees, 219 had lateral OA, 260 medial OA, and 849 no OA. Hip and pelvic measurements were taken from full-limb radiographs on the ipsilateral side of the knee of interest. After adjusting for covariates, means were compared between sexes and also between knees with medial and lateral OA vs no OA using separate regression models. Results Women were shown to have a reduced femoral offset (FO) (mean 40.9 mm vs 45.9 mm; P  = 0.001) and more valgus neck-shaft angle (mean 128.4° vs 125.9°; P