Dietary tryptophan modulates intestinal immune response, barrier function, antioxidant status and gene expression of TOR and Nrf2 in young grass carp (Ctenopharyngodon idella)

• Published in: Fish & shellfish immunology 2014-09, Vol.40 (1), p.275-287
• Main Authors: Wen, Hailang, Feng, Lin, Jiang, Weidan, Liu, Yang, Jiang, Jun, Li, Shuhong, Tang, Ling, Zhang, Yongan, Kuang, Shengyao, Zhou, Xiaoqiu
• Format: Article
• Language: English
• Subjects: Animal Feed - analysis; Animals; Antioxidant status; Antioxidants - metabolism; Carps - genetics; Carps - immunology; Diet - veterinary; Dietary Supplements - analysis; Fish Proteins - genetics; Fish Proteins - metabolism; Gene Expression Regulation - drug effects; Immune response; Immunity, Innate - drug effects; Intestines - drug effects; Intestines - immunology; Molecular Sequence Data; NF-E2-Related Factor 2 - genetics; NF-E2-Related Factor 2 - metabolism; Nrf2; Real-Time Polymerase Chain Reaction - veterinary; Sequence Analysis, DNA - veterinary; Tight junction protein; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism; Tryptophan; Tryptophan - administration & dosage; Tryptophan - pharmacology
• ISSN: 1050-4648; 1095-9947
• DOI: 10.1016/j.fsi.2014.07.004

The present research evaluated the effects of dietary tryptophan (Trp) on growth performance, intestinal mucosal immune, barrier function and antioxidant capacity and gene expression of young grass carp (Ctenopharyngodon idella). Fish were fed six different experimental diets containing graded levels of Trp at 0.7(control), 1.7, 3.1, 4.0, 5.2 and 6.1 g kg−1 diet for 8 weeks. The results showed that Trp supplementation significantly enhanced the percent weight gain (PWG), feed intake and feed efficiency (P