Diagnosis of leishmaniasis

Leishmaniasis is a clinically heterogeneous syndrome caused by intracellular protozoan parasites of the genus Leishmania. The clinical spectrum of leishmaniasis encompasses subclinical (not apparent), localized (skin lesion), and disseminated (cutaneous, mucocutaneous, and visceral) infection. This...

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Bibliographic Details
Published in:Journal of infection in developing countries 2014-08, Vol.8 (8), p.961-972
Main Authors: Elmahallawy, Ehab Kotb, Sampedro Martinez, Antonio, Rodriguez-Granger, Javier, Hoyos-Mallecot, Yannick, Agil, Ahamd, Navarro Mari, Jose Mari, Gutierrez Fernandez, Jose
Format: Article
Language:English
Subjects:
Clinical Laboratory Techniques - methods
Diagnostic Tests, Routine - methods
Humans
Leishmania - isolation & purification
Leishmaniasis - diagnosis
Leishmaniasis - immunology
Leishmaniasis - pathology
Parasitic diseases
Protozoa
Serologic Tests - methods
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Summary:Leishmaniasis is a clinically heterogeneous syndrome caused by intracellular protozoan parasites of the genus Leishmania. The clinical spectrum of leishmaniasis encompasses subclinical (not apparent), localized (skin lesion), and disseminated (cutaneous, mucocutaneous, and visceral) infection. This spectrum of manifestations depends on the immune status of the host, on the parasite, and on immunoinflammatory responses. Visceral leishmaniasis causes high morbidity and mortality in the developing world. Reliable laboratory methods become mandatory for accurate diagnosis, especially in immunocompromised patients such as those infected with HIV. In this article, we review the current state of the diagnostic tools for leishmaniasis, especially  the serological test.
ISSN:1972-2680
2036-6590
1972-2680
DOI:10.3855/jidc.4310