Facile Preparation of Mussel-Inspired Polyurethane Hydrogel and Its Rapid Curing Behavior

A facile method was found to incorporate a mussel-inspired adhesive moiety into synthetic polymers, and mussel mimetic polyurethanes were developed as adhesive hydrogels. In these polymers, a urethane backbone was substituted for the polyamide chain of mussel adhesive proteins, and dopamine was appe...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2014-08, Vol.6 (15), p.12495-12504
Main Authors: Sun, Peiyu, Wang, Jing, Yao, Xiong, Peng, Ying, Tu, Xiaoxiong, Du, Pengfei, Zheng, Zhen, Wang, Xinling
Format: Article
Language:English
Subjects:
Animals
Biomimetics - methods
Bivalvia - chemistry
Catechols - chemistry
Cross-Linking Reagents - chemistry
Dopamine - chemistry
Esters - chemistry
Hydrogel, Polyethylene Glycol Dimethacrylate - chemical synthesis
Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry
Hydrogen-Ion Concentration
Iodates - chemistry
Iron - chemistry
Ligands
Lysine - chemistry
Molecular Weight
Oxidation-Reduction
Polyurethanes - chemical synthesis
Polyurethanes - chemistry
Proton Magnetic Resonance Spectroscopy
Rheology
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
Thermogravimetry
Time Factors
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Summary:A facile method was found to incorporate a mussel-inspired adhesive moiety into synthetic polymers, and mussel mimetic polyurethanes were developed as adhesive hydrogels. In these polymers, a urethane backbone was substituted for the polyamide chain of mussel adhesive proteins, and dopamine was appended to mimic the adhesive moiety of adhesive proteins. A series of mussel mimetic polyurethanes were created through a step-growth polymerization based on hexamethylene diisocyanate as a hard segment, PEG having different molecular weights as a soft segment, and lysine-dopamine as a chain extender. Upon a treatment with Fe3+, the aqueous mussel mimetic polyurethane solutions can be triggered by pH adjustment to form adhesive hydrogels instantaneously; these materials can be used as injectable adhesive hydrogels. Upon a treatment with NaIO4, the mussel mimetic polyurethane solutions can be cured in a controllable period of time. The successful combination of the unique mussel-inspired adhesive moiety with a tunable polyurethane structure can result in a new kind of mussel-inspired adhesive polymers.
ISSN:1944-8244
1944-8252
DOI:10.1021/am502106e