The arabinitol appearance rate in laboratory animals and humans: Estimation from the arabinitol/creatinine ratio and relevance to the diagnosis of candididasis

The effect of renal function on serum concentrations of the candidal metabolite arabinitol were studied by examining the accumulation and elimination of arabinitol in animals and humans. Serum concentrations of arabinitol rose sharply and in direct proportion to creatinine concentrations after nephr...

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Bibliographic Details
Published in:The Journal of infectious diseases 1982-01, Vol.146 (3), p.353-359
Main Authors: Wong, B, Bernard, E M, Gold, JWM, Fong, D, Armstrong, D
Format: Article
Language:English
Subjects:
candida
Candida albicans
Candida parapsilosis
Candida tropicalis
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Summary:The effect of renal function on serum concentrations of the candidal metabolite arabinitol were studied by examining the accumulation and elimination of arabinitol in animals and humans. Serum concentrations of arabinitol rose sharply and in direct proportion to creatinine concentrations after nephrectomy in rats. The serum half-life of exogenous arabinitol was 20.8 hr in anephric rats but only 0.62 hr in shamnephrectomized control animals. The mean plus or minus SD apparent space of distribution of arabinitol was 419 plus or minus 26 ml/kg. The arabinitol/creatinine clearance ratio was 0.99 plus or minus 0.08 in normal dogs and 0.99 plus or minus 0.25 in 22 critically ill patients with cancer. Thus arabinitol is eliminated by nearly quantitative urinary excretion and is cleared at virtually the same rate as creatinine. Therefore, the rate of arabinitol appearance in the body from any source equals the urinary arabinitol excretion rate and is directly proportional to the concentration ratio of arabinitol to creatinine in serum or urine.
ISSN:0022-1899