Embryotoxicity of 4-deoxynivalenol (vomitoxin) in mice [Poisoning from consumption of moldy cereal grain]

During a poisoning outbreak of swine in 1972, researchers isolated a mycotoxin from moldy corn contaminated with Fusarium graminearum and named it vomitoxin since vomiting had been the salient sign of intoxication. The isolated toxin produced, upon feeding, similar signs in pigs. However, it was not...

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 1982-10, Vol.29 (4), p.487-491
Main Authors: Khera, K S, Whalen, C, Angers, G, Vesonder, R F, Kuiper-Goodman, T
Format: Article
Language:English
Subjects:
Animals
Diarrhea - chemically induced
Female
Fetal Resorption - chemically induced
Fusarium graminearum
Gestational Age
Hemorrhage - chemically induced
Mice
Pregnancy
Sesquiterpenes - toxicity
Teratogens
Trichothecenes - toxicity
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Summary:During a poisoning outbreak of swine in 1972, researchers isolated a mycotoxin from moldy corn contaminated with Fusarium graminearum and named it vomitoxin since vomiting had been the salient sign of intoxication. The isolated toxin produced, upon feeding, similar signs in pigs. However, it was not certain whether this toxin which caused emesis in pigs was identical to the mycotoxin responsible for emesis in man. It was later found that feeds contaminated with vomitoxin or 4-deoxynivalenol was rejected by pigs.
ISSN:0007-4861
1432-0800
DOI:10.1007/bf01605616