The Role of Monoacylglycerol Lipase (MAGL) in the Cancer Progress

In recent years, metabolism is talked highly important in cancer research, especially the lipid metabolism. Researchers believe that the de novo fatty acid synthesis plays an important role in tumor development, while many studies illustrated that Endocannabinoids have anti-tumorigenic actions, incl...

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Bibliographic Details
Published in:Cell biochemistry and biophysics 2014-09, Vol.70 (1), p.33-36
Main Authors: Qin, Hong, Ruan, Zhi-hua
Format: Article
Language:English
Subjects:
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biotechnology
Cell Biology
Disease Progression
Endocannabinoids - metabolism
Humans
Life Sciences
Lipid Metabolism
Monoacylglycerol Lipases - metabolism
Neoplasms - enzymology
Neoplasms - metabolism
Pharmacology/Toxicology
Review Paper
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Summary:In recent years, metabolism is talked highly important in cancer research, especially the lipid metabolism. Researchers believe that the de novo fatty acid synthesis plays an important role in tumor development, while many studies illustrated that Endocannabinoids have anti-tumorigenic actions, including anti-proliferation, apoptosis induction, and anti-metastatic effects, MAGL as an important decomposing enzyme of both lipid metabolism and endocannabinoids system, additionally as a part of a gene expression signature contributes to different aspects of tumourigenesis.
ISSN:1085-9195
1559-0283
DOI:10.1007/s12013-014-9899-2