Exercise capacity in adolescent and adult patients with post infectious bronchiolitis obliterans

• Published in: Pediatric pulmonology 2014-09, Vol.49 (9), p.911-918
• Main Authors: Frohlich, Luiz Felipe, Vieira, Paulo J.C., Teixeira, Paulo José Zimermann, Silva, Fernando Abreu, Ribeiro, Jorge P., Berton, Danilo C.
• Format: Article
• Language: English
• Subjects: Adolescent; bronchiolitis; Bronchiolitis Obliterans - physiopathology; Case-Control Studies; Child; Cross-Sectional Studies; Exercise Test; Exercise Tolerance - physiology; Female; Humans; Male; Oxygen Consumption - physiology; pulmonary function testing (PFT); Respiratory Function Tests; Retrospective Studies; Sampling Studies; Young Adult
• ISSN: 8755-6863; 1099-0496
• DOI: 10.1002/ppul.22929

Background Post‐infectious bronchiolitis obliterans (PBO) is a chronic lung disease characterized by the persistence of continuous obstructive respiratory symptoms following an acute and severe respiratory infection in children under 3 years old. The purpose of the present study was to investigate if adolescents and adults with diagnosis of PBO have reduced aerobic capacity and identify factors related with exercise performance. Methods A convenience sample of 16 patients (10–23 years) that have consulted with established diagnosis of PBO in a tertiary care clinic were studied. Fourteen healthy matched subjects were selected from the community to serve as controls. They performed resting lung function tests and cycle incremental cardiopulmonary exercise tests. Results Peak aerobic capacity (peak V˙O2) was significantly lower in patients compared to controls (84 ± 15 vs. 101 ± 17% pred; P