Randomised clinical trial: polyethylene glycol 3350 with sports drink vs. polyethylene glycol with electrolyte solution as purgatives for colonoscopy – the incidence of hyponatraemia

Summary Background Polyethylene glycol 3350 plus sports drink (PEG‐SD) is a hypo‐osmotic purgative commonly used for colonoscopy, though little safety data are available. Aim To evaluate the effect of PEG‐SD on serum sodium (Na) and other electrolytes compared with PEG‐electrolyte solution (PEG‐ELS)...

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Bibliographic Details
Published in:Alimentary pharmacology & therapeutics 2014-09, Vol.40 (6), p.610-619
Main Authors: Matro, R., Daskalakis, C., Negoianu, D., Katz, L., Henry, C., Share, M., Kastenberg, D.
Format: Article
Language:English
Subjects:
Aged
Beverages
Biological and medical sciences
Cathartics - adverse effects
Cathartics - therapeutic use
Chlorides - blood
Colonoscopy
Digestive system
Electrolytes - adverse effects
Electrolytes - therapeutic use
Female
Humans
Hyponatremia - blood
Hyponatremia - chemically induced
Male
Medical sciences
Middle Aged
Outpatients
Pharmacology. Drug treatments
Polyethylene Glycols - adverse effects
Polyethylene Glycols - therapeutic use
Potassium - blood
Sodium - blood
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Summary:Summary Background Polyethylene glycol 3350 plus sports drink (PEG‐SD) is a hypo‐osmotic purgative commonly used for colonoscopy, though little safety data are available. Aim To evaluate the effect of PEG‐SD on serum sodium (Na) and other electrolytes compared with PEG‐electrolyte solution (PEG‐ELS). Methods We performed a single center, prospective, randomised, investigator‐blind comparison of PEG‐ELS to PEG‐SD in out‐patients undergoing colonoscopy. Laboratories were obtained at baseline and immediately before and after colonoscopy. The primary endpoint was development of hyponatraemia (Na
ISSN:0269-2813
1365-2036
DOI:10.1111/apt.12884