Bone Marrow Transplantation of Mice Exposed to a Modified Fission Neutron (N/G-30:1) Field

A special exposure design was used in conjunction with the Armed Forces Radiobiology Research Institute's Training Research Isotope General Atomic Reactor to yield a fission neutron dose-to-γ dose (N/G) ratio of 30:1. The${\rm LD}_{50/30}$for mice exposed in this facility was 371 ± 4 rad, while...

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Bibliographic Details
Published in:Radiation research 1982-11, Vol.92 (2), p.268-279
Main Authors: Stewart, D. A., Ledney, G. D., Baker, W. H., Daxon, E. G., Sheehy, P. A.
Format: Article
Language:English
Subjects:
Animals
Bone marrow
Bone marrow cells
Bone Marrow Transplantation
Dose-Response Relationship, Radiation
Dosimetry
Estimate reliability
Fast Neutrons
Gamma Rays
Hematopoiesis - radiation effects
Irradiation
Male
Mice
Mice, Inbred Strains
Mortality
Neutrons
Radiation dosage
Radiation Injuries, Experimental - etiology
Radiation Injuries, Experimental - therapy
Relative Biological Effectiveness
Time Factors
Whole-Body Irradiation
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Summary:A special exposure design was used in conjunction with the Armed Forces Radiobiology Research Institute's Training Research Isotope General Atomic Reactor to yield a fission neutron dose-to-γ dose (N/G) ratio of 30:1. The${\rm LD}_{50/30}$for mice exposed in this facility was 371 ± 4 rad, while 879 ± 14 rad (RBE-2.4) was the${\rm LD}_{50/30}$for mice exposed to60Co. A marrow dose range of 375 to 425 rad was found in which mice exposed in the modified fission field died 8-15 days later, a time frame characteristic of hematopoietic failure. In this dose range, 5× 106syngeneic marrow cells resulted in 77% 30-day survival. The number of bone marrow cells needed to rescue neutron-irradiated mice was greater than the number needed to rescue^{60}{\rm Co}\text{-irradiated}$mice.
ISSN:0033-7587
1938-5404
DOI:10.2307/3576004