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In vivo magnetic resonance imaging at 11.7 Tesla visualized the effects of neonatal transection of infraorbital nerve upon primary and secondary trigeminal pathways in rats
Abstract Using 11.7 T ultra high-field T2-weighted MRI, the present study aimed to investigate pathological changes of primary and secondary trigeminal pathways following neonatal transection of infraorbital nerve in rats. The trigeminal pathways consist of spinal trigeminal tract, trigeminal sensor...
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| Published in: | Brain research 2014-09, Vol.1579, p.84-92 |
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| container_title | Brain research |
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| creator | Ooi, Yasuhiro Inui-Yamamoto, Chizuko Suzuki, Takashi Nakadate, Hiromichi Nagase, Yoshitaka Seiyama, Akitoshi Yoshioka, Yoshichika Seki, Junji |
| description | Abstract Using 11.7 T ultra high-field T2-weighted MRI, the present study aimed to investigate pathological changes of primary and secondary trigeminal pathways following neonatal transection of infraorbital nerve in rats. The trigeminal pathways consist of spinal trigeminal tract, trigeminal sensory nuclear complex, medial lemniscus, ventromedial portion of external medullary lamina and ventral posterior nucleus of thalamus. By selecting optimum parameters of MRI such as repetition time, echo time, and slice orientation, this study visualized the trigeminal pathways in rats without any contrast agents. Pathological changes due to the nerve transection were found at 8 weeks of age as a marked reduction of the areas of the trigeminal pathways connecting from the injured nerve. In addition, T2-weighted MR images of the trigeminal nerve trunk and the spinal trigeminal tract suggest a communication of CSF through the trigeminal nerve between the inside and outside of the brain stem. These results support the utility of ultra high-field MRI system for noninvasive assessment of effects of trigeminal nerve injury upon the trigeminal pathways. |
| doi_str_mv | 10.1016/j.brainres.2014.07.013 |
| format | article |
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The trigeminal pathways consist of spinal trigeminal tract, trigeminal sensory nuclear complex, medial lemniscus, ventromedial portion of external medullary lamina and ventral posterior nucleus of thalamus. By selecting optimum parameters of MRI such as repetition time, echo time, and slice orientation, this study visualized the trigeminal pathways in rats without any contrast agents. Pathological changes due to the nerve transection were found at 8 weeks of age as a marked reduction of the areas of the trigeminal pathways connecting from the injured nerve. In addition, T2-weighted MR images of the trigeminal nerve trunk and the spinal trigeminal tract suggest a communication of CSF through the trigeminal nerve between the inside and outside of the brain stem. These results support the utility of ultra high-field MRI system for noninvasive assessment of effects of trigeminal nerve injury upon the trigeminal pathways.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2014.07.013</identifier><identifier>PMID: 25038563</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Animals, Newborn ; Biological and medical sciences ; Critical period ; Fundamental and applied biological sciences. Psychology ; Magnetic Resonance Imaging ; Male ; Maxillary Nerve - injuries ; Neonatal nerve transaction ; Neural Pathways - pathology ; Neurology ; Rats ; Rats, Wistar ; Thalamus - pathology ; Trigeminal Ganglion - pathology ; Trigeminal Nerve - pathology ; Trigeminal Nuclei - pathology ; Trigeminal pathways ; Ultra high-field T2-weighted MR imaging ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 2014-09, Vol.1579, p.84-92</ispartof><rights>Elsevier B.V.</rights><rights>2014 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c637t-77ff6047bd24c49c13e9143bdf30608fe94dad8bff2baeffa9ce915b17c54cf63</citedby><cites>FETCH-LOGICAL-c637t-77ff6047bd24c49c13e9143bdf30608fe94dad8bff2baeffa9ce915b17c54cf63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28740331$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25038563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ooi, Yasuhiro</creatorcontrib><creatorcontrib>Inui-Yamamoto, Chizuko</creatorcontrib><creatorcontrib>Suzuki, Takashi</creatorcontrib><creatorcontrib>Nakadate, Hiromichi</creatorcontrib><creatorcontrib>Nagase, Yoshitaka</creatorcontrib><creatorcontrib>Seiyama, Akitoshi</creatorcontrib><creatorcontrib>Yoshioka, Yoshichika</creatorcontrib><creatorcontrib>Seki, Junji</creatorcontrib><title>In vivo magnetic resonance imaging at 11.7 Tesla visualized the effects of neonatal transection of infraorbital nerve upon primary and secondary trigeminal pathways in rats</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Abstract Using 11.7 T ultra high-field T2-weighted MRI, the present study aimed to investigate pathological changes of primary and secondary trigeminal pathways following neonatal transection of infraorbital nerve in rats. The trigeminal pathways consist of spinal trigeminal tract, trigeminal sensory nuclear complex, medial lemniscus, ventromedial portion of external medullary lamina and ventral posterior nucleus of thalamus. By selecting optimum parameters of MRI such as repetition time, echo time, and slice orientation, this study visualized the trigeminal pathways in rats without any contrast agents. Pathological changes due to the nerve transection were found at 8 weeks of age as a marked reduction of the areas of the trigeminal pathways connecting from the injured nerve. In addition, T2-weighted MR images of the trigeminal nerve trunk and the spinal trigeminal tract suggest a communication of CSF through the trigeminal nerve between the inside and outside of the brain stem. These results support the utility of ultra high-field MRI system for noninvasive assessment of effects of trigeminal nerve injury upon the trigeminal pathways.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biological and medical sciences</subject><subject>Critical period</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Maxillary Nerve - injuries</subject><subject>Neonatal nerve transaction</subject><subject>Neural Pathways - pathology</subject><subject>Neurology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Thalamus - pathology</subject><subject>Trigeminal Ganglion - pathology</subject><subject>Trigeminal Nerve - pathology</subject><subject>Trigeminal Nuclei - pathology</subject><subject>Trigeminal pathways</subject><subject>Ultra high-field T2-weighted MR imaging</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFks2OFCEQgInRuOPqK2y4mHiZFhq66b4YzcafTTbx4HomNBSzjD30CPSY8Zl8SKszs5p48UQovqqi-CDkirOKM96-3lZDMiEmyFXNuKyYqhgXj8iKd6pet7Vkj8mKMdauu74XF-RZzlvcCtGzp-SibpjomlasyK-bSA_hMNGd2UQowVIsOUUTLdCAsRA31BTKeaXoHeTRIJ1nM4af4Gi5Bwregy2ZTp5GwMRiRlqSiRmjYYpLPESfzJSGsJxFSAeg8x6P9gk7pCM10VHEp-iWXUlhA7sQkd2bcv_DHDNWoMmU_Jw88WbM8OK8XpKvH97fXX9a337-eHP97nZtW6HKWinvWybV4GppZW-5gJ5LMTgvWMs6D710xnWD9_Vg8P6mtwg0A1e2kda34pK8OtXdp-n7DLnoXcgWxtHgiHPWvGmkbDvJFKLtCbVpyjmB1-epNGd6MaW3-sGUXkxppjSawsSrc4952IH7k_agBoGXZ8Bka0Z8wmhD_st1SqJOjtzbEwf4IocASWcbAP25kNCBdlP4_13e_FPCjiEG7PoNjpC305xQB86tc62Z_rL8q-VbcclYL2sufgORqs6t</recordid><startdate>20140904</startdate><enddate>20140904</enddate><creator>Ooi, Yasuhiro</creator><creator>Inui-Yamamoto, Chizuko</creator><creator>Suzuki, Takashi</creator><creator>Nakadate, Hiromichi</creator><creator>Nagase, Yoshitaka</creator><creator>Seiyama, Akitoshi</creator><creator>Yoshioka, Yoshichika</creator><creator>Seki, Junji</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140904</creationdate><title>In vivo magnetic resonance imaging at 11.7 Tesla visualized the effects of neonatal transection of infraorbital nerve upon primary and secondary trigeminal pathways in rats</title><author>Ooi, Yasuhiro ; Inui-Yamamoto, Chizuko ; Suzuki, Takashi ; Nakadate, Hiromichi ; Nagase, Yoshitaka ; Seiyama, Akitoshi ; Yoshioka, Yoshichika ; Seki, Junji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c637t-77ff6047bd24c49c13e9143bdf30608fe94dad8bff2baeffa9ce915b17c54cf63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biological and medical sciences</topic><topic>Critical period</topic><topic>Fundamental and applied biological sciences. 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The trigeminal pathways consist of spinal trigeminal tract, trigeminal sensory nuclear complex, medial lemniscus, ventromedial portion of external medullary lamina and ventral posterior nucleus of thalamus. By selecting optimum parameters of MRI such as repetition time, echo time, and slice orientation, this study visualized the trigeminal pathways in rats without any contrast agents. Pathological changes due to the nerve transection were found at 8 weeks of age as a marked reduction of the areas of the trigeminal pathways connecting from the injured nerve. In addition, T2-weighted MR images of the trigeminal nerve trunk and the spinal trigeminal tract suggest a communication of CSF through the trigeminal nerve between the inside and outside of the brain stem. 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| subjects | Animals Animals, Newborn Biological and medical sciences Critical period Fundamental and applied biological sciences. Psychology Magnetic Resonance Imaging Male Maxillary Nerve - injuries Neonatal nerve transaction Neural Pathways - pathology Neurology Rats Rats, Wistar Thalamus - pathology Trigeminal Ganglion - pathology Trigeminal Nerve - pathology Trigeminal Nuclei - pathology Trigeminal pathways Ultra high-field T2-weighted MR imaging Vertebrates: nervous system and sense organs |
| title | In vivo magnetic resonance imaging at 11.7 Tesla visualized the effects of neonatal transection of infraorbital nerve upon primary and secondary trigeminal pathways in rats |
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