Effect of Heat Shock Protein 90 (Hsp90) on Migration and Invasion of Human Cancer Cells in Vitro

We studied the effect of purifi ed native heat shock protein 90 (Hsp90) from bovine and mouse brain on migration and invasion of human glioblastoma (A-172) and fi brosarcoma (HT1080) cells. Hsp90 in concentrations of 0.01-0.10 mg/ml stimulated migration and invasion of tumor cells in vitro by 20-32%...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-08, Vol.157 (4), p.476-478
Main Authors: Snigireva, A. V., Vrublevskaya, V. V., Skarga, Yu. Yu, Evdokimovskaya, Yu. V., Morenkov, O. S.
Format: Article
Language:English
Subjects:
Animals
Antibodies - pharmacology
Biomedical and Life Sciences
Biomedicine
Brain Chemistry
Cancer
Cattle
Cell Biology
Cell Line, Tumor
Cell Movement - drug effects
Diffusion Chambers, Culture
Extracellular Matrix Proteins - pharmacology
Fibroblasts - cytology
Fibroblasts - drug effects
Heat shock proteins
HSP70 Heat-Shock Proteins - antagonists & inhibitors
HSP70 Heat-Shock Proteins - isolation & purification
HSP70 Heat-Shock Proteins - pharmacology
HSP90 Heat-Shock Proteins - antagonists & inhibitors
HSP90 Heat-Shock Proteins - isolation & purification
HSP90 Heat-Shock Proteins - pharmacology
Internal Medicine
Laboratory Medicine
Mice
Neuroglia - cytology
Neuroglia - drug effects
NIH 3T3 Cells
Pathology
Sarcoma
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Summary:We studied the effect of purifi ed native heat shock protein 90 (Hsp90) from bovine and mouse brain on migration and invasion of human glioblastoma (A-172) and fi brosarcoma (HT1080) cells. Hsp90 in concentrations of 0.01-0.10 mg/ml stimulated migration and invasion of tumor cells in vitro by 20-32% ( p
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2595-9