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A positive association of vitamin D deficiency and sarcopenia in 50 year old women, but not men
Summary Background & aims Sarcopenia, loss of muscle mass and function, is one of the major risk factors for metabolic diseases and vitamin D is also positively associated with their prevalence. We examined whether vitamin D deficiency was positively associated with sarcopenia in a gender-specif...
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| Published in: | Clinical nutrition (Edinburgh, Scotland) Scotland), 2014-10, Vol.33 (5), p.900-905 |
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| container_title | Clinical nutrition (Edinburgh, Scotland) |
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| creator | Park, Sunmin Ham, Jung-O Lee, Byung-Kook |
| description | Summary Background & aims Sarcopenia, loss of muscle mass and function, is one of the major risk factors for metabolic diseases and vitamin D is also positively associated with their prevalence. We examined whether vitamin D deficiency was positively associated with sarcopenia in a gender-specific manner in adults aged ≥50 years, independent of other covariates and possible confounders, including body composition, blood tests, including serum parathyroid hormone (PTH) levels, dietary intake, and hormone replacement therapy in women. Methods This cross-sectional study included 2258 men and 3005 women aged ≥50 years who participated in the 2009–2010 Korean National Health and Nutrition Examination Survey. Sarcopenia was defined as appendicular skeletal muscle mass/body weight |
| doi_str_mv | 10.1016/j.clnu.2013.09.016 |
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We examined whether vitamin D deficiency was positively associated with sarcopenia in a gender-specific manner in adults aged ≥50 years, independent of other covariates and possible confounders, including body composition, blood tests, including serum parathyroid hormone (PTH) levels, dietary intake, and hormone replacement therapy in women. Methods This cross-sectional study included 2258 men and 3005 women aged ≥50 years who participated in the 2009–2010 Korean National Health and Nutrition Examination Survey. Sarcopenia was defined as appendicular skeletal muscle mass/body weight <2 standard deviations below gender-specific means for young adults. Vitamin D status was represented by serum 25-hydroxyvitamin D (25-OH-D) levels. Adjusted odds ratios for having sarcopenia were calculated according to vitamin D status, while controlling for covariates that affect vitamin D status and body composition using logistic regression analysis with incorporating the sample weights for the complex sample design of the survey. Results Sarcopenia showed a strong inverse association with serum 25-OH-D levels in women, but not men, independent of other covariates and possible confounders. Sarcopenia was negatively associated with dietary intakes of energy, protein, and carbohydrates in both men and women, but walking and exercise showed no significant relationship with sarcopenic status. Sarcopenic status was significantly associated with serum total 25-OH-D and cholesterol levels only in women and with serum PTH levels only in men. The risk of sarcopenia was increased, by 1.46-fold, by lowering serum 25-OH-D by 10 ng/mL only in women. Conclusions Serum 25-OH-D levels were a negative modulator of sarcopenia only in women aged ≥50 years in a Korean population.</description><identifier>ISSN: 0261-5614</identifier><identifier>EISSN: 1532-1983</identifier><identifier>DOI: 10.1016/j.clnu.2013.09.016</identifier><identifier>PMID: 24140234</identifier><identifier>CODEN: CLNUDP</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Aged ; Asian Continental Ancestry Group ; Biological and medical sciences ; Body Composition ; Body Mass Index ; Body Weight ; Cross-Sectional Studies ; Dietary intake ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology and Hepatology ; Gender-specific ; Humans ; Logistic Models ; Male ; Middle Aged ; Muscle, Skeletal - physiology ; Nutrition Surveys ; Parathyroid hormone ; Parathyroid Hormone - blood ; Prevalence ; Republic of Korea - epidemiology ; Risk Factors ; Sarcopenia ; Sarcopenia - blood ; Sarcopenia - epidemiology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin D ; Vitamin D - blood ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - epidemiology</subject><ispartof>Clinical nutrition (Edinburgh, Scotland), 2014-10, Vol.33 (5), p.900-905</ispartof><rights>Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>2013 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-59ee75fb481f3b43bd6d911e6313b0dffbd9555af08410f94c278293d4bc20003</citedby><cites>FETCH-LOGICAL-c511t-59ee75fb481f3b43bd6d911e6313b0dffbd9555af08410f94c278293d4bc20003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28741232$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24140234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Sunmin</creatorcontrib><creatorcontrib>Ham, Jung-O</creatorcontrib><creatorcontrib>Lee, Byung-Kook</creatorcontrib><title>A positive association of vitamin D deficiency and sarcopenia in 50 year old women, but not men</title><title>Clinical nutrition (Edinburgh, Scotland)</title><addtitle>Clin Nutr</addtitle><description>Summary Background & aims Sarcopenia, loss of muscle mass and function, is one of the major risk factors for metabolic diseases and vitamin D is also positively associated with their prevalence. We examined whether vitamin D deficiency was positively associated with sarcopenia in a gender-specific manner in adults aged ≥50 years, independent of other covariates and possible confounders, including body composition, blood tests, including serum parathyroid hormone (PTH) levels, dietary intake, and hormone replacement therapy in women. Methods This cross-sectional study included 2258 men and 3005 women aged ≥50 years who participated in the 2009–2010 Korean National Health and Nutrition Examination Survey. Sarcopenia was defined as appendicular skeletal muscle mass/body weight <2 standard deviations below gender-specific means for young adults. Vitamin D status was represented by serum 25-hydroxyvitamin D (25-OH-D) levels. Adjusted odds ratios for having sarcopenia were calculated according to vitamin D status, while controlling for covariates that affect vitamin D status and body composition using logistic regression analysis with incorporating the sample weights for the complex sample design of the survey. Results Sarcopenia showed a strong inverse association with serum 25-OH-D levels in women, but not men, independent of other covariates and possible confounders. Sarcopenia was negatively associated with dietary intakes of energy, protein, and carbohydrates in both men and women, but walking and exercise showed no significant relationship with sarcopenic status. Sarcopenic status was significantly associated with serum total 25-OH-D and cholesterol levels only in women and with serum PTH levels only in men. The risk of sarcopenia was increased, by 1.46-fold, by lowering serum 25-OH-D by 10 ng/mL only in women. Conclusions Serum 25-OH-D levels were a negative modulator of sarcopenia only in women aged ≥50 years in a Korean population.</description><subject>Aged</subject><subject>Asian Continental Ancestry Group</subject><subject>Biological and medical sciences</subject><subject>Body Composition</subject><subject>Body Mass Index</subject><subject>Body Weight</subject><subject>Cross-Sectional Studies</subject><subject>Dietary intake</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology and Hepatology</subject><subject>Gender-specific</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal - physiology</subject><subject>Nutrition Surveys</subject><subject>Parathyroid hormone</subject><subject>Parathyroid Hormone - blood</subject><subject>Prevalence</subject><subject>Republic of Korea - epidemiology</subject><subject>Risk Factors</subject><subject>Sarcopenia</subject><subject>Sarcopenia - blood</subject><subject>Sarcopenia - epidemiology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitamin D</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - epidemiology</subject><issn>0261-5614</issn><issn>1532-1983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp9kkuLFDEURgtRnJ7RP-BCshFcTLW5edQDZGAYnzDgQl2HVHIDaauSNqlq6X9vym4VXLgKuTnfTXK4VfUM6BYoNK92WzOGZcso8C3tt6X0oNqA5KyGvuMPqw1lDdSyAXFRXea8o5RK3naPqwsmQFDGxaZSt2Qfs5_9AYnOORqvZx8DiY4c_KwnH8gbYtF54zGYI9HBkqyTiXsMXpNyLCk5ok4kjpb8iBOGazIsMwlxJmXzpHrk9Jjx6Xm9qr6-e_vl7kN9_-n9x7vb-9pIgLmWPWIr3SA6cHwQfLCN7QGw4cAHap0bbC-l1I52AqjrhWFtx3puxWBY-Re_ql6e-u5T_L5gntXks8Fx1AHjkhVIKUTTt7QpKDuhJsWcEzq1T37S6aiAqlWs2qlVrFrFKtqrUiqh5-f-yzCh_RP5bbIAL86AzkaPLulgfP7Lda0AxlnhXp84LDYOHpPKv9Si9QnNrGz0_3_HzT9xM_rgy43f8Ih5F5cUimcFKjNF1ed1BNYJAE4pkw3jPwEEyqoJ</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Park, Sunmin</creator><creator>Ham, Jung-O</creator><creator>Lee, Byung-Kook</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20141001</creationdate><title>A positive association of vitamin D deficiency and sarcopenia in 50 year old women, but not men</title><author>Park, Sunmin ; Ham, Jung-O ; Lee, Byung-Kook</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-59ee75fb481f3b43bd6d911e6313b0dffbd9555af08410f94c278293d4bc20003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Asian Continental Ancestry Group</topic><topic>Biological and medical sciences</topic><topic>Body Composition</topic><topic>Body Mass Index</topic><topic>Body Weight</topic><topic>Cross-Sectional Studies</topic><topic>Dietary intake</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology and Hepatology</topic><topic>Gender-specific</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle, Skeletal - physiology</topic><topic>Nutrition Surveys</topic><topic>Parathyroid hormone</topic><topic>Parathyroid Hormone - blood</topic><topic>Prevalence</topic><topic>Republic of Korea - epidemiology</topic><topic>Risk Factors</topic><topic>Sarcopenia</topic><topic>Sarcopenia - blood</topic><topic>Sarcopenia - epidemiology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitamin D</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Sunmin</creatorcontrib><creatorcontrib>Ham, Jung-O</creatorcontrib><creatorcontrib>Lee, Byung-Kook</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Sunmin</au><au>Ham, Jung-O</au><au>Lee, Byung-Kook</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A positive association of vitamin D deficiency and sarcopenia in 50 year old women, but not men</atitle><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle><addtitle>Clin Nutr</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>33</volume><issue>5</issue><spage>900</spage><epage>905</epage><pages>900-905</pages><issn>0261-5614</issn><eissn>1532-1983</eissn><coden>CLNUDP</coden><abstract>Summary Background & aims Sarcopenia, loss of muscle mass and function, is one of the major risk factors for metabolic diseases and vitamin D is also positively associated with their prevalence. We examined whether vitamin D deficiency was positively associated with sarcopenia in a gender-specific manner in adults aged ≥50 years, independent of other covariates and possible confounders, including body composition, blood tests, including serum parathyroid hormone (PTH) levels, dietary intake, and hormone replacement therapy in women. Methods This cross-sectional study included 2258 men and 3005 women aged ≥50 years who participated in the 2009–2010 Korean National Health and Nutrition Examination Survey. Sarcopenia was defined as appendicular skeletal muscle mass/body weight <2 standard deviations below gender-specific means for young adults. Vitamin D status was represented by serum 25-hydroxyvitamin D (25-OH-D) levels. Adjusted odds ratios for having sarcopenia were calculated according to vitamin D status, while controlling for covariates that affect vitamin D status and body composition using logistic regression analysis with incorporating the sample weights for the complex sample design of the survey. Results Sarcopenia showed a strong inverse association with serum 25-OH-D levels in women, but not men, independent of other covariates and possible confounders. Sarcopenia was negatively associated with dietary intakes of energy, protein, and carbohydrates in both men and women, but walking and exercise showed no significant relationship with sarcopenic status. Sarcopenic status was significantly associated with serum total 25-OH-D and cholesterol levels only in women and with serum PTH levels only in men. The risk of sarcopenia was increased, by 1.46-fold, by lowering serum 25-OH-D by 10 ng/mL only in women. Conclusions Serum 25-OH-D levels were a negative modulator of sarcopenia only in women aged ≥50 years in a Korean population.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>24140234</pmid><doi>10.1016/j.clnu.2013.09.016</doi><tpages>6</tpages></addata></record> |
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| ispartof | Clinical nutrition (Edinburgh, Scotland), 2014-10, Vol.33 (5), p.900-905 |
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| source | ScienceDirect Journals |
| subjects | Aged Asian Continental Ancestry Group Biological and medical sciences Body Composition Body Mass Index Body Weight Cross-Sectional Studies Dietary intake Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastroenterology and Hepatology Gender-specific Humans Logistic Models Male Middle Aged Muscle, Skeletal - physiology Nutrition Surveys Parathyroid hormone Parathyroid Hormone - blood Prevalence Republic of Korea - epidemiology Risk Factors Sarcopenia Sarcopenia - blood Sarcopenia - epidemiology Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin D Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - epidemiology |
| title | A positive association of vitamin D deficiency and sarcopenia in 50 year old women, but not men |
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