Membranoproliferative Glomerulonephritis in a Calf with Nephrotic Syndrome

A 2-month-old Japanese black calf was presented with a history of weight loss, exophthalmos and subcutaneous oedema of the brisket. Urinalysis and serum biochemistry showed proteinuria and hypoproteinaemia suggestive of nephrotic syndrome. Microscopically, lesions in the kidney were characterized by...

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Bibliographic Details
Published in:Journal of comparative pathology 2014-08, Vol.151 (2-3), p.162-165
Main Authors: Trang, N.T., Hirai, T., Nabeta, R., Fuke, N., Yamaguchi, R.
Format: Article
Language:English
Subjects:
Animals
bovine viral diarrhoea virus
Bovine Virus Diarrhea-Mucosal Disease - pathology
Bovine Virus Diarrhea-Mucosal Disease - virology
calf
Cattle
Diarrhea Virus 1, Bovine Viral
Fluorescent Antibody Technique
glomerulonephritis
Glomerulonephritis, Membranoproliferative - pathology
Glomerulonephritis, Membranoproliferative - veterinary
Glomerulonephritis, Membranoproliferative - virology
kidney
Microscopy, Electron
Nephrotic Syndrome - pathology
Nephrotic Syndrome - veterinary
Nephrotic Syndrome - virology
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Summary:A 2-month-old Japanese black calf was presented with a history of weight loss, exophthalmos and subcutaneous oedema of the brisket. Urinalysis and serum biochemistry showed proteinuria and hypoproteinaemia suggestive of nephrotic syndrome. Microscopically, lesions in the kidney were characterized by proliferation of mesangial cells and diffuse thickening of the glomerular basement membranes with the appearance of double contours. Immune complex deposits were confirmed by electron microscopy and immunofluorescence using reagents specific for bovine immunoglobulin G, complement factor C3 and bovine viral diarrhoea virus (BVDV). Consequently, the glomerular lesion in this case was diagnosed as membranoproliferative glomerulonephritis. BVDV type 1 was detected in serum by nested reverse transcriptase polymerase chain reaction. Viral antigen was also identified in the glomeruli by immunofluorescence. These results suggest that BVDV may have been the cause of immune complex glomerulonephritis in this calf.
ISSN:0021-9975
1532-3129
DOI:10.1016/j.jcpa.2014.05.001