Tumour localization of monoclonal antibody against a rat mammary carcinoma and suppression of tumour growth with adriamycin-antibody conjugates

Monoclonal antibody to the rat mammary carcinoma Sp4 isolated from hybridoma supernatants and labelled with super(125)I showed preferential in vivo localization into subcutaneous growths of Sp4 compared with normal tissues and a range of other transplanted tumours. No specific localization was seen...

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Bibliographic Details
Published in:Cancer Immunology Immunotherapy 1982-02, Vol.12 (2), p.125-134
Main Authors: Pimm, MalcolmV, Jones, JeanA, Price, MichaelR, Middle, JohnG, Embleton, MichaelJ, Baldwin, RobertW
Format: Article
Language:English
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Summary:Monoclonal antibody to the rat mammary carcinoma Sp4 isolated from hybridoma supernatants and labelled with super(125)I showed preferential in vivo localization into subcutaneous growths of Sp4 compared with normal tissues and a range of other transplanted tumours. No specific localization was seen with super(125)I-labelled normal rat immunoglobulin. Adriamycin conjugated to monoclonal antibody significantly retarded Sp4 tumour growth at 1/25th of the effective dose of the free drug, and in some cases brought about total tumour regression. Normal rat immunoglobulin-adriamycin conjugates were relatively ineffective. These studies indicate that monoclonal antibody directed against tumour cell surface antigens may be highly effective for tumour targeting of therapeutic agents.
ISSN:0340-7004
1432-0851
DOI:10.1007/BF00205370